Global trends in the burden of alcohol use disorders in the working-age population from 1990 to 2021 and projections for the next 20 years

作者：Xinyu Cui, Kexin Liu, Yuanyi Ji, Su Myat Han, Yongzhong Cheng · 发表于：Frontiers in Public Health · 年份：2025 · DOI：10.3389/fpubh.2025.1616343 · 被引用次数：3 · 研究领域：Substance Abuse Treatment and Outcomes、Alcoholism and Thiamine Deficiency、Cancer Research and Treatment

Introduction Alcohol use disorders (AUD) have long been among the most disabling mental disorders and a leading cause of health loss. However, data on the burden and trends of these disorders among the working-age population are scarce. Methods This study aimed to assess trends in the burden of AUD among people aged 15-64 years from 1990 to 2021 at the global, regional and national levels and to project future trends. Based on the trend analysis of the Global Burden of Disease Study 2021 (GBD2021), we report age-standardized data and estimated annual percentage changes (EAPC) for the incidence, prevalence, mortality, and disability-adjusted life years (DALYs) of AUD in the working-age population at the global, regional, and national levels and analyze global trends by age, sex, and social development index (SDI). Furthermore, critical inflection points and local trends Average Annual Percent Change (AAPC) were further explored via joinpoint regression analysis, and the burden of AUD was predicted via the Bayesian age-period-cohort (BAPC) model. Results Globally, the incidence number of AUD cases among people aged 15-64 years in 2021 was estimated to be 51340.37 × 10 3 (95%UI 37577.93 × 10 3 −68135.93 × 10 3 ). During the period from 1990 to 2021,the age-standardized incidence rate (ASIR) (EAPC = −0.85, 95%CI: −0.89 to −0.81, p < 0.05), age-standardized mortality rate(ASMR) (EAPC = −1.98, 95%CI: −2.43 to −1.54, p < 0.05) and age-standardized disability-adjusted l...