The relationship between elderly nutritional risk index and short-term all-cause mortality in critically ill patients with cerebral injury: a retrospective cohort study from two cohorts

作者：Zirong Gao, Xiaoqiang Mo, Yi Ge, Yanhui Lu, Shanshan Yu · 发表于：Frontiers in Nutrition · 年份：2025 · DOI：10.3389/fnut.2025.1620364 · 被引用次数：7 · 研究领域：Nutrition and Health in Aging、Clinical Nutrition and Gastroenterology、Frailty in Older Adults

Background: The Geriatric Nutritional Risk Index (GNRI) is a simple and objective tool for assessing the risk of malnutrition, with potential practicality in critically ill patients with cerebral injury (CIPCI). However, the current evidence is still limited. Method: Patients diagnosed with cerebral injury were retrospectively retrieved from the Medical Information Marketplace for Intensive Care (MIMIC-IV) and the Affiliated Jinyang Hospital of Guizhou Medical University. Various statistical methods, including restricted cubic spline regression (RCS) regression, multivariate logistic regression, subgroup analyses, and KM survival curves, were used to examine the association between the GNRI index and short-term adverse outcomes in CIPCI. Finally, we used LASSO-COX regression and multifactorial COX regression to develop risk prediction models and assessed the validity of the risk models using subject work characteristics (ROC) curves, area under the ROC (AUC). Result: The final 1,244 CIPCIs were included in the analysis, of which the 28-day ICU/in-hospital mortality rates were 23.5 and 27.18%, respectively. In the fully adjusted model, continuous GNRI and GNRI category were significantly associated with 28-day ICU/in-hospital mortality, with HRs of, respectively, continuous GNRI: 0.97 (0.96-0.99)/0.97 (0.96-0.99) and [moderate nutritional risk vs. no nutritional risk: 1.66 (1.01-2.74) and 2.03 (1.26-3.28), higher nutritional risk vs. no nutritional risk: 1.79 (1.08-2.97)/2.11 ...