Charting structural brain asymmetry across the human lifespan

作者：Lena Dorfschmidt, Simon R. White, Margaret Gardner, Saashi A. Bedford, Gareth Ball, A. David Edwards, Yuanjun Gu, Yuankai He, Hao Huang, Shivaram Karandikar, Vanessa Kyriakopoulou, Minhui Ouyuang, Elmo P. Pulli, Armin Raznahan, Emma C. Robinson, Rafael Romero-Garcia, Theodore D. Satterthwaite, Jenna Schabdach, Isaac Sebenius, Zhiqiang Sha, Russell T. Shinohara, Jetro J. Tuulari, Matilde M. Vaghi, Jacob W. Vogel, František Váša, Logan Z. J. Williams, Dabriel Zimmerman, Varun Warrier, Konrad Wagstyl, Edward T. Bullmore, Richard A. I. Bethlehem, Jakob Seidlitz, Aaron Alexander‐Bloch · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2025 · DOI：10.1101/2025.07.21.665924 · 被引用次数：9 · 研究领域：Hemispheric Asymmetry in Neuroscience、Functional Brain Connectivity Studies、Morphological variations and asymmetry

Lateralization is a fundamental principle of structural brain organization. In vivo imaging of brain asymmetry is essential for deciphering lateralized brain functions and their disruption in neurodevelopmental and neurodegenerative disorders. Here, we present a normative framework for benchmarking brain asymmetry across the lifespan, developed from an aggregated sample of 128 primary neuroimaging studies, including 177,701 scans from 138,231 individuals, jointly spanning the age range from 20 post menstrual weeks to 102 years. This resource includes comprehensive, hemisphere-specific brain growth charts for multiple neuroimaging phenotypes: regional cortical grey matter volume, thickness, surface area, and subcortical volumes. Our findings reveal distinct spatial patterns of asymmetry, with early leftward asymmetry observed in association cortices and late rightward asymmetry in sensory regions. These trajectories support theories of the neuroplasticity of asymmetry and the role of both genetic and environmental factors in shaping brain lateralization. Additionally, we provide tools to generate asymmetry centile scores, which allow the quantification of individual deviations from typical asymmetry throughout the lifespan and can be applied to unseen data or clinical populations. We demonstrate the utility of these models by highlighting group-level differences in asymmetry in autism spectrum disorder, schizophrenia, and Alzheimer's disease, and exploring genetic correlations...