Predictive value of vaginal lactic acid bacteria changes on occurrence of HR-HPV-infected cervical intraepithelial neoplasia and construction and validation of nomogram model

作者：Ying Huang, Yu-liang Shen, Xuemei Wei, Jie Feng, Lin Zhu · 发表于：BMC Cancer · 年份：2025 · DOI：10.1186/s12885-025-14604-z · 被引用次数：4 · 研究领域：Reproductive tract infections research、Cervical Cancer and HPV Research、Preterm Birth and Chorioamnionitis

OBJECTIVE: To explore the predictive value of vaginal lactic acid bacteria changes on the occurrence of HR-HPV infected cervical intraepithelial neoplasia (CIN), and to construct and validate Nomogram model. METHODS: The community composition, quantitative distribution and other indicators of vaginal lactic acid bacteria in patients with and without CIN were detected and analyzed. The key lactic acid bacteria characteristics and other potential risk factors related to CIN were screened out using statistical methods, and then the Nomogram prediction model was constructed. The model discrimination was assessed by the receiver operating characteristic (ROC) and the calibration curves, and decision curves analysis (DCA) was performed to verify the reliability of the model. RESULTS: There was no significant difference in the incidence of CIN, baseline data and vaginal lactic acid bacteria parameters between the training set and the verification set (P > 0.05). Univariate analysis identified significant differences in clinical factors (e.g., age of first sexual activity, safety measures) and vaginal lactobacilli (e.g., L. acidophilus, L. jenseni, L. gasseri, L. rhamnosus) between groups (P < 0.05). Multivariate Logistic regression confirmed safety measures, serum progesterone levels, and relative abundances of L. acidophilus, L. crispatus, L. jenseni, and L. rhamnosus as independent risk factors for CIN (P < 0.05). Further, the nomogram prediction model was constructed, and the nom...