Association of gastroesophageal reflux disease with the incidence of pulmonary disease

作者：X. Wang, Yan Wang, Yijie Bu, Yu Liu, Sheng Gong, Guowei Che · 发表于：Frontiers in Cell and Developmental Biology · 年份：2025 · DOI：10.3389/fcell.2025.1552126 · 被引用次数：6 · 研究领域：Gastroesophageal reflux and treatments、Eosinophilic Esophagitis、Gut microbiota and health

Objective: Concurrent pulmonary diseases are common in patients with gastroesophageal reflux disease (GERD). However, whether GERD increase the incidence of pulmonary diseases is uncertain because of a lack of quantitative evidence. We conducted a meta-analysis to determine whether GERD was associated with the increased incidence of subsequent of pulmonary diseases. Methods: The PubMed, Embase, Web of Science and Cochrane Library databases were searched through 12 July 2024. The primary outcomes were asthma and pneumonia, and the secondary outcomes were pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), lung cancer, interstitial lung disease (ILD), bronchiectasis, bronchitis, acute lung injury (ALI), pulmonary embolism, pulmonary tuberculosis (PTB) and nontuberculous mycobacterial pulmonary disease (NTMPD). Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to investigate the associations of prior GERD with the incidence of pulmonary diseases, and subgroup analyses based on the treatment of GERD, age and source of OR were performed. Results: A total of 45 cohort studies were included. The pooled results indicated that GERD was significantly linked to an increased incidence of asthma (OR = 1.50, P < 0.001) and pneumonia (OR = 1.53, P < 0.001), as did PF (OR = 1.43, P = 0.001), COPD (OR = 1.41, P = 0.004), lung cancer (OR = 1.51, P < 0.001), ILD (OR = 1.28, P = 0.015), bronchiectasis (OR = 1.63, P = 0.039), bronchitis (OR = 1.24, P < 0.001...