Bivalent prefusion F vaccination in pregnancy and respiratory syncytial virus hospitalisation in infants in the UK: results of a multicentre, test-negative, case-control study

作者：Thomas Williams, Robin Marlow, Steve Cunningham, Simon B. Drysdale, Helen Groves, Samantha Hunt, Dalia Iskander, Xinxue Liu, Mark D Lyttle, Chengetai D Mpamhanga, Shaun O’Hagan, Thomas Waterfield, Damian Roland, Catriona M Middleton, Maggie Connon, Jill M Paxton, Nicola Thomson, James Thomas Baker, Susie R Hardwick, Karena Jan Fraser, Kathryn Frances Kimber, Asa JE French, Meriel FJ Tolhurst-Cleaver, Sarah Siner, Stephen Fletcher, Karen Geoghegan, Laura Ann Tremarco, Kelly Curran, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Richard Benjamin Stuart Berg, Sara Mohammed Osman Farah, Elena Kehtarnavaz, Abigail Louise Whitehouse, Grace E Wild, Sobia Siraj, Ioannis Kyrgios, Amutha Anpananthar, Lee James Tubman, Sunil S Bhopal, Jessica Reynolds, Gabrielle Larkin, Elizabeth Ledger, Ruth E Bonsor, Dodd Hopgood, Robert Eggen, Katy Lillie, Mat Stuart, Alison O'Kelly, Chiara De Leonardis, Stephen P Brearey, Caroline A Burchett, Sarah E de-Beger, Claire Bell, Babu G Benjamin, Sarah E Farmer, Mudiyur Gopi, Natalie Keenan, Jen G Browning, Caroline Blackstock, Rachel O'Brien, Sylvester S Gomes, Gracita M Woods, Dilini Vasanthakumar, Kayleigh Kanhai, Heather J Jarman, Zee R Karame, Steve J Foster, Susanne Cathcart, Louise E Edwards, James R Poole-Cowley, Samantha E Hunt, Joanne L Tomlinson, Jo William Tillett, Simon R Dowson, Surendra T Singham, Perpetual S Palmer, Eilidh E Grant, Pauline Miller, Kelum K Perera, Jasmine L Stares, Manuela E Brazil, Sharryn Gardner, Kerri Bowness, Moira Morrison, Nicholas Richens, Heather Deall, Jemma Parratt, Stephanie - Grigsby, Nina Vanner, Francesca Diaz, Graham Johnson, Jonathan Riley, Alison Fletcher, Lianne Hufton, Alison Rockey, Alison Matthews, Claire Fearn, Elisha Cousins, Katie Louise Bub, Cynthia Dzokoto Diaba, Chidinma Joanne Iheanetu-Oguejiofor, Lobsong Dolma, Stephen Waithaka Ruo, Elena Kehtarnavaz, George R Hamson, Hannah Randall, Jessica J Evans, Virginia J Griffiths, Sarah L Diment, Sebastian J Gray, Nikki Leanne Furness, Stuart Gormley, Rebecca Scott, Victoria Bamber, Kathryn Jones, Megan Wilcock, Louise A Fairlie, Rophy Ganancial Nunes, Niall G Mullen, Clare O'Leary, Kerri Bowness, Richard George Burridge, Katrina S Hall, Leanne M Taylor, Lily J Kirkpatrick, Erum Jamall, Grace Wild, David Hartin, Rebecca Francis, Genevieve Nguya, Deborah Beeby · 发表于：The Lancet Child & Adolescent Health · 年份：2025 · DOI：10.1016/s2352-4642(25)00155-5 · 被引用次数：33 · 研究领域：Respiratory viral infections research、COVID-19 Impact on Reproduction、COVID-19 Clinical Research Studies

BACKGROUND: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in infants younger than 6 months globally. A maternal bivalent RSV prefusion F (RSVpreF) vaccine was introduced to the UK in late summer in 2024 (August 12 in Scotland and September 1 in England), with all pregnant women at 28 weeks or more of gestation eligible for vaccination. We aimed to understand RSVpreF vaccine effectiveness in a real-world setting. METHODS: We conducted a multicentre, test-negative, case-control study to analyse the vaccine effectiveness of maternal RSVpreF vaccination against the primary outcome of hospitalisation (ie, admission to hospital) for RSV-associated ALRI in infants. Patient and public involvement from a group of parents informed the study protocol design. Included patients were infants with ALRI born after Aug 12, 2024 (Scotland), and Sept 1, 2024 (England), and therefore had mothers eligible for maternal vaccination, who were admitted to 30 hospital sites across the UK from Sept 30, 2024, to Jan 20, 2025, and tested for RSV. Infants were followed up until hospital discharge or death as an inpatient. Primary vaccine effectiveness of maternal RSVpreF vaccination against RSV-associated hospitalisation was calculated with the use of a conditional logistic regression adjusted by site, calendar month of hospital attendance for the infant, age, preterm birth, and sex. FINDINGS: We included 537 mother-infant pairs, in whom there were 391...