Ciprofol vs propofol for gastrointestinal endoscopy sedation: a systematic review and meta-analysis

作者：Yunfeng Yu, Juan Deng, Yuman Yin, Xinyu Yang, Liao Min, Rong Yu · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000003064 · 被引用次数：8 · 研究领域：Anesthesia and Sedative Agents、Colorectal Cancer Screening and Detection、Nausea and vomiting management

BACKGROUND: Ciprofol, a propofol derivative, is increasingly used for sedation in China. However, the specific benefits of ciprofol in gastrointestinal endoscopic sedation have not been fully evaluated. This meta-analysis aimed to compare the efficacy and safety of ciprofol with propofol in gastrointestinal endoscopy. METHODS: Four public databases were searched for the relevant literature to February 1, 2025. Studies were excluded based on predefined criteria, and the characteristics and outcome data of each included study were collected. Subsequently, meta-analysis and trial sequential analysis (TSA) were performed using Review Manager 5.3 and TSA 0.9.5.10 Beta, respectively. RESULTS: Nine studies involving 1860 participants were included in this study. Compared with propofol, ciprofol significantly reduced rates of hypotension (risk ratio [RR] 0.75, 95% confidence interval [CI] 0.63-0.89), respiratory depression (RR 0.71, 95% CI 0.56-0.91), hypoxemia (RR 0.65, 95% CI 0.48-0.87), choking cough (RR 0.74, 95% CI 0.57-0.95), and injection pain (RR 0.11, 95% CI 0.06-0.22). Awakening time of ciprofol was slightly prolonged (mean difference 0.81 minutes, 95% CI 0.02-1.61), though not clinically significant. Bradycardia, involuntary movement, dizziness, nausea, and vomiting were comparable between the two groups ( P > 0.05). Moreover, TSA demonstrated that the results of hypotension, hypoxemia, respiratory depression, and injection pain observed in the current sample size were dec...