Manual acupuncture for the treatment of chronic spontaneous urticaria: a systematic review and meta-analysis

作者：Yunfeng Yu, Jingyi Wu, Gang Hu, Juan Deng, Xinyu Yang, Rong Yu · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000002887 · 被引用次数：7 · 研究领域：Urticaria and Related Conditions、Coagulation, Bradykinin, Polyphosphates, and Angioedema、Drug-Induced Adverse Reactions

BACKGROUND: The benefits and risks of manual acupuncture for treating chronic spontaneous urticaria (CSU) remain unclear. To address this gap, this systematic review and meta-analysis aimed to evaluate the efficacy and safety of manual acupuncture for treating CSU. METHODS: Seven major databases were searched for relevant literature published up to 1 January 2025. Studies were selected based on pre-specified criteria, and relevant information was extracted. A meta-analysis was conducted using Review Manager 5.3. RESULTS: Six randomized controlled trials involving 615 participants were included. Compared with sham or non-acupuncture, a 4-week manual acupuncture treatment significantly reduced the values of the urticaria activity score over 7 days (weighted mean difference [WMD] -3.43; 95% confidence interval [CI] -5.27 to -1.60; P = 0.0002), Dermatology Life Quality Index (WMD -2.16; 95% CI -3.78 to -0.54; P = 0.009), Pittsburgh Sleep Quality Index (WMD -1.25; 95% CI -1.69 to -0.81; P < 0.00001), Hamilton Anxiety Rating Scale (WMD -2.97; 95% CI -4.05 to -1.89; P < 0.00001), and Hamilton Depression Rating Scale (WMD -2.55; 95% CI -3.43 to -1.66; P < 0.00001). These improvements remained significantly different at 4-weeks post-treatment. Although manual acupuncture was associated with an increased incidence of subcutaneous hemorrhage (risk ratio 4.52; 95% CI 1.06 to 19.29; P = 0.04), no significant effect on the incidence of total adverse events, dizziness, fatigue, or acupunctu...