Global, regional, and national prevalence of kidney failure with replacement therapy and associated aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

作者：Quinn Rafferty, Lauryn K Stafford, Theo Vos, Fernando Saldanha Thomé, Hasan Aalruz, Yohannes Abate, Cristiana Abbafati, Samar Abd ElHafeez, Armita Abedi, Olugbenga Olusola Abiodun, Lucas Guimarães Abreu, Eman Abu‐Gharbieh, Salahdein Aburuz, Ahmed Abu‐Zaid, Lawan Hassan Adamu, Isaac Yeboah Addo, Oyelola A. Adegboye, Victor Abiola Adepoju, Olorunsola Adeyomoye, Qorinah Estiningtyas Sakilah Adnani, Sanjay Agarwal, Shahin Aghamiri, Krishna Kumar Agrawaal, Bright Opoku Ahinkorah, Aqeel Ahmad, Muayyad Ahmad, Sajjad Ahmad, Ali Ahmed, Ayman Ahmed, Syed Anees Ahmed, Marjan Ajami, Shiva Akhlaghi, Sreelatha Akkala, Ziyad Al‐Aly, Mohammed ALBashtawy, Khalifah A Aldawsari, Hediyeh Alemi, Adel Al‐Gheethi, Fadwa Alhalaiqa, Endale Alemayehu Ali, Syed Shujait Ali, Omar Almidani, Rajaa M Mohammad Al-Raddadi, Farrukh Jawad Alvi, Nelson Alvis‐Guzmán, Nelson J Alvis-Zakzuk, Yaser Mohammed Al‐Worafi, Safwat Aly, Karem H. Alzoubi, Reza Amani, Hubert Amu, Ganiyu Adeniyi Amusa, Cătălina Liliana Andrei, Abhishek Anil, Adnan Ansar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Elshaimaa A Arafa, Mesay Arkew, Johan Ärnlöv, Tahira Ashraf, Mohammad Athar, Seyyed Shamsadin Athari, Maha Atout, Adedapo Wasiu Awotidebe, Zewdu Bishaw Aynalem, Sina Azadnajafabad, Hamed Azhdari Tehrani, Shahkaar Aziz, Hassan Babamohamadi, Muhammad Badar, Arvind Bagga, Sara Bagherieh, Ovidiu Constantin Baltatu, Hiba Jawdat Barqawi, Sanjay Basu, Saurav Basu, Kavita Batra, Nebiyou Simegnew Bayileyegn, Neeraj Bedi, Amir Hossein Behnoush, Alehegn Bekele, Luı́s Belo, Bright Benfor, Isabela M. Benseñor, Amiel Nazer C Bermudez, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Gurjit Kaur Bhatti, Jasvinder Singh Bhatti, Ali Bijani, Boris Bikbov, Mariah Malak Bilalaga, Veera Raghavulu Bitra, Kaustubh Bora, Yasser Bustanji, Zahid A Butt, Luis Alberto Cámera, Juan Jesús Carrero, Márcia Carvalho, Ferrán Catalá-López, Alberico L. Catapano, Muthia Cenderadewi, Joshua Chadwick, Promit Ananyo Chakraborty, Eeshwar K Chandrasekar, Vijay Kumar Chattu, Endeshaw Chekol Abebe, Patrick R Ching, E. Chowdhury, Rajiv Chowdhury, Dinh‐Toi Chu, Sheng‐Chia Chung, Massimo Círillo, Alyssa Columbus, Josef Coresh, Natália Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Saswati Das, Mohadese Dashtkoohi, Mogamat Razeen Davids, Iván Delgado‐Enciso, Berecha Hundessa Demessa, Xin Deng, Hardik Dineshbhai Desai, Vinoth Gnana Chellaiyan Devanbu, Syed Masudur Rahman Dewan, Daniel Díaz, Lankamo Ena Digesa, Abhinav Dixit, Thao Huynh Phuong, Camila Bruneli do Prado, Khanh Duy Doan, Клара Докова, Deepa Dongarwar, Robert Kokou Dowou, Hisham Atan Edinur, Michael Ekholuenetale, Temitope Cyrus Ekundayo, Muhammed Elhadi, Waseem El‐Huneidi, Mohamed A. Elmonem, Christopher Imokhuede Esezobor, Francesco Esposito, Farshid Etaee, Adeniyi Francis Fagbamigbe, Razana Faiz, Aida Fallahzadeh, Emerito Jose A Faraon, Alireza Feizkhah, Ginenus Fekadu, Nuno Ferreira, Bikila Regassa Feyisa, Florian Fischer, Abduzhappar Gaipov, Aravind P. Gandhi, Miglas Welay Gebregergis, Mathewos Mekonnen, Mansour Ghafourifard, Ibrahim Ginawi, Ebisa Zerihun Gindaba, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Shi‐Yang Guan, Mesay Dechasa Gudeta, Anish Kumar Gupta, Rajat Das Gupta, Rajeev Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Gupta, Najah R Hadi, Hailey Hagins, Teklehaimanot Gereziher Haile, Sobia Ahsan Halim, Rabih Halwani, Nadia Μ. Hamdy, Samer Hamidi, Ahmad Hammoud, Habtamu Endashaw Hareru, S M Mahmudul Hasan, Md Saquib Hasnain, Johannes Haubold, Jiawei He, Keyvan Heydari, Yuta Hiraike, Praveen Hoogar, Hassan Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Hong-Han Huynh, Segun Emmanuel Ibitoye, Irena Ilić, Md. Rabiul Islam, Sheikh Mohammed Shariful Islam, Muhammad Islampanah, Nahlah Elkudssiah Ismail, Hiroyasu Iso, Gaetano Isola, Masao Iwagami, Chidozie Declan Iwu, Mahboobeh Jafari, Khushleen Jaggi, Ammar Abdulrahman Jairoun, Sathish Kumar Jayapal, Shubha Jayaram, Vivekanand Jha, Jost B. Jonas, Abel Joseph, Nitin Joseph, Charity Ehimwenma Joshua, Ali Kabir, Vineet Kumar Kamal, Himal Kandel, Kehinde Kazeem Kanmodi, Ibraheem M. Karaye, Ronit Katz, Tsegaye Melaku Kebede, Mohammad Keykhaei, Yousef Khader, Himanshu Khajuria, Amirmohammad Khalaji, Mohammad Jobair Khan, Moien AB Khan, Haitham Khatatbeh, Moawiah Khatatbeh, Sorour Khateri, Feriha Fatima Khidri, Sepehr Khosravi, Biruk Getahun Kibret, Adnan Kısa, Farzad Kompani, Oleksii Korzh, Karel Kostev, Sindhura Lakshmi Koulmane Laxminarayana, Kewal Krishan, Hare Krishna, Barthélémy Kuate Defo, Mohammed Kuddus, Avinash Kumar, G Anil Kumar, Rakesh Kumar, Maria Dyah Kurniasari, Ambily Kuttikkattu, Chandrakant Lahariya, Tuo Lan, Thao Thi Thu Le, Trang Thi Bich Le, Caterina Ledda, Munjae Lee, Seung Won Lee, Wei‐Chen Lee, Zhihui Li, Lee‐Ling Lim, Stephen S Lim, Shuke Liu, Chun‐Han Lo, László Lorenzovici, Giancarlo Lucchetti, Hawraz Ibrahim M. Amin, Sandeep Maharaj, Amir Ali Mahboobipour, Mansour Adam Mahmoud, Reza Malekzadeh, Kashish Malhotra, Ahmad Azam Malik, Emmanuel Kwaku Manu, Patrick B. Mark, Winfried März, Elezebeth Mathews, Andrea Maugeri, Stephen P. McDonald, Steven McPhail, Hadush Negash Meles, Mohsen Merati, Tomislav Mestrovic, Tomasz Miazgowski, Niloofar Mirdamadi, Erkin М Мirrakhimov, Vinaytosh Mishra, Nouh Saad Mohamed, Mustapha Mohammed, Shafiu Mohammed, Alireza Mohseni, Ali H. Mokdad, AmirAli Moodi Ghalibaf, Yousef Moradi, Linda Morales‐Juárez, Negar Morovatdar, Parsa Mousavi, Kavita Munjal, Efrén Murillo‐Zamora, Ahmad Mustafa, Muhammad Muzaffar, Shankar Prasad Nagaraju, Mohsen Naghavi, Pirouz Naghavi, Tapas Sadasivan Nair, Jobert Richie Nansseu, Abdallah Y. Naser, Gopalakrishnan Natarajan, Zuhair S. Natto, Ashish Nayyar, Athare Nazri-Panjaki, Mohammad Negaresh, Ruxandra Irina Negoi, Nawi Ng, Dang Nguyen, Hau Thi Hien Nguyen, Hien Quang Nguyen, Phat Tuan Nguyen, Van Thanh Nguyen, Robina Khan Niazi, Muhammad A Nizam, Mamoona Noreen, Jean Jacques Noubiap, Chisom Adaobi Nri-Ezedi, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Hassan Okati‐Aliabad, Osaretin Christabel Okonji, Andrew T Olagunju, Tosin A. Olasehinde, Hany A. Omar, Alberto Ortíz, Wael M S Osman, Uchechukwu Levi Osuagwu, Mayowa Owolabi, Ifeoluwa T. Oyeyemi, Alicia Padrón‐Monedero, Jagadish Rao Padubidri, Anamika Pandey, Shahina Pardhan, Romil R Parikh, Seoyeon Park, Maja Pasovic, Jay Patel, Shrikant Pawar, Prince Peprah, Norberto Perico, Simone Perna, Hoang Tran Pham, Anil K. Philip, Elton Junio Sady Prates, Jagadeesh Puvvula, Ibrahim Qattea, Mosiur Rahman, Muhammad Aziz Rahman, Masoud Rahmati, Shakthi Kumaran Ramasamy, Sheena Ramazanu, Indu Ramachandra Rao, Drona Rasali, Sina Rashedi, Ahmed Mustafa Rashid, Mohammad‐Mahdi Rashidi, Ashkan Rasouli‐Saravani, Zubair Ahmed Ratan, Salman Rawaf, Murali Mohan Rama Krishna Reddy, Elrashdy M. Redwan, Giuseppe Remuzzi, Nazila Rezaei, Aziz Rezapour, Jefferson Antonio Buendía, Leonardo Roever, Peter Rohloff, Debby Syahru Romadlon, Godfrey Mutashambara Rwegerera, Aly M A Saad, Basema Ahmad Saddik, Umar Saeed, Maryam Saeedi, Sher Zaman Safi, Fatemeh Saheb Sharif‐Askari, Amirhossein Sahebkar, Soumya Swaroop Sahoo, Monalisha Sahu, Afeez Abolarinwa Salami, Luciane Bresciani Salaroli, Mohamed A. Saleh, Hossein Salehi Omran, Yoseph Leonardo Samodra, Vijaya Paul Samuel, Juan Sanabria, Francesco Sanmarchi, Itamar S Santos, Aswini Saravanan, Saman Sargazi, T. Sarkar, Arash Sarveazad, Jennifer Saulam, Monika Sawhney, Art Schuermans, Aletta E. Schutte, Sabyasachi Senapati, Sadaf G Sepanlou, Sidharth Kumar Sethi, Yashendra Sethi, SeyedAhmad SeyedAlinaghi, Allen Seylani, Saeed Shahabi, Masood Ali Shaikh, Muhammad Aaqib Shamim, Amin Sharifan, Javad Sharifi‐Rad, Bereket Beyene Shashamo, Aminu Shittu, Abdul-karim Olayinka Shitu, Sunil Shrestha, Migbar Mekonnen Sibhat, Ambrish Singh, Mahendra Singh, Narinder Pal Singh, Paramdeep Singh, Surjit Singh, Rajiv Sinha, Ranjan Solanki, Shipra Solanki, Yonatan Solomon, Vianda S Stel, Jacqueline H. Stephens, Muhammad Suleman, Jing Sun, Johan Sundström, Hani Susianti, Chandan Kumar Swain, Łukasz Szarpak, Sree Sudha T Y, Seyyed Mohammad Tabatabaei, Shima Tabatabai, Mohammad Tabish, Iman M. Talaat, Jacques Lukenze Tamuzi, Roberto Tanchanco, Wubshet Tesfaye, Edosa Tesfaye Geta, Riki Tesler, Pugazhenthan Thangaraju, Jansje Henny Vera Ticoalu, Marcello Tonelli, Domenico Tricò, Vien T. Truong, Thien Tan Tri Tai Truyen, Aristidis Tsatsakis, Guesh Mebrahtom Tsegay, Abdul Rohim Tualeka, Munkhtuya Tumurkhuu, Aniefiok John Udoakang, Sahel Valadan Tahbaz, Rohollah Valizadeh, Jef Van den Eynde, Priya Vart, Shoban Babu Varthya, Madhur Verma, Massimiliano Veroux, Georgios‐Ioannis Verras, Loc Vu, Henok Toga Wada, Yasir Waheed, Fang Wang, Muhammad Waqas, Ronny Westerman, Yifan Wu, Suowen Xu, Habib Yaribeygi, Dong Keon Yon, Naohiro Yonemoto, Mazyar Zahir, Sojib Bin Zaman, Nelson Zamora, Moein Zangiabadian, Iman Zare, Haijun Zhang, Hanqing Zhao, Jingjing Zhou, Magdalena Zielińska, Yossef Teshome Zikarg, Samer H. Zyoud, Bruce Bartholow Duncan, Simon I Hay, Christopher J L Murray, Kanyin Liane Ong · 发表于：The Lancet Global Health · 年份：2025 · DOI：10.1016/s2214-109x(25)00198-6 · 被引用次数：101 · 研究领域：Renal Transplantation Outcomes and Treatments、Dialysis and Renal Disease Management、Chronic Kidney Disease and Diabetes

BACKGROUND: Kidney failure with replacement therapy (KFRT) such as dialysis or transplantation represents a severe stage of chronic kidney disease (CKD) and poses a major global health burden. Although many CKD cases are diagnosed in the earlier stages, the greatest risk occurs when CKD progresses to KFRT. Despite its considerable financial and imposing impact on public health, there is a notable gap in international policies addressing CKD and KFRT. To bridge this gap and help policy makers and health systems effectively tackle the public health challenge of KFRT, a better understanding of the disease burden is essential. Thus, this analysis aims to provide a detailed overview of the global prevalence of KFRT and its associated aetiologies with estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) from 1990 to 2023. METHODS: This study defined KFRT as individuals on maintenance dialysis for 90 days or more or those who have undergone a kidney transplant, aligning with the Kidney Disease: Improving Global Outcomes (KDIGO) 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Renal registries served as the primary data sources. Prevalence and underlying aetiology estimates (type 1 diabetes, type 2 diabetes, hypertension, glomerulonephritis, and other causes) were generated with DisMod-MR 2.1, an epidemiological Bayesian mixed-effects meta-regression modelling tool. Both all-age and age-standardised estimate...