High Burden of Symptomatic and Asymptomatic Sexually Transmitted Infections in a Routine Decentralised HIV Care Setting in Eswatini: A Cross‐Sectional Study

作者：Bernhard Kerschberger, Nombuso Ntshalintshali, Mano Isaac Mafomisa, Edwin Mabhena, Michelle Daka, Esther Mukooza, Skinner Lekelem, Sindisiwe Dlamini, Mpumelelo Mavimbela, Lenhle Dube, Sindy Matse, Nomvuyo Mabuza, Roberto de Latour, Laurence Toutous Trellu, Hayk Karakozian, Nelly Staderini, Melat Haile, Pablo Valladares, Alexandra Calmy, Iza Ciglenečki · 发表于：Tropical Medicine & International Health · 年份：2025 · DOI：10.1111/tmi.70011 · 被引用次数：4 · 研究领域：Reproductive tract infections research、Adolescent Sexual and Reproductive Health、Cervical Cancer and HPV Research

OBJECTIVES: Sexually transmitted infections are a global public health concern. We aimed to assess the burden of a diverse range of sexually transmitted infections in a high HIV burden setting in Eswatini and associated risk factors. METHODS: This cross-sectional study enrolled adults accessing routine outpatient care at six sites in Shiselweni, from July 2022 to April 2023. Laboratory investigations included antibody-based tests for HIV, Treponema pallidum , hepatitis B, hepatitis C, and herpes simplex 2 viruses. The molecular-based Xpert platform tested urine samples for Chlamydia trachomatis , Neisseria gonorrhoea, Trichomonas vaginalis, self-collected vaginal/anal swabs for Human papillomavirus, and plasma for HIV viremia. We calculated the proportion of laboratory-confirmed sexually transmitted infections among available test results and identified predictors of combined Chlamydia trachomatis /Neisseria gonorrhoea/Trichomonas vaginalis infection. RESULTS: Of 1396 study participants, 65.4% were women, the median age was 29 (IQR 23-36) years, and 19.6% were known HIV-positive. Overall, 68.6% had symptoms suggestive of Chlamydia trachomatis /Neisseria gonorrhoea/Trichomonas vaginalis infections. Laboratory-confirmed Chlamydia trachomatis /Neisseria gonorrhoea/Trichomonas vaginalis infection was found in 31.7% (n = 443/1396), of whom 20.8% were asymptomatic. Combined Chlamydia trachomatis /Neisseria gonorrhoea/Trichomonas vaginalis infections were common even among individua...