Protein post-translational modifications: Novel molecular switches and strategies for targeted therapy in ischemic heart disease

作者：Yuanyuan Chen, Gaojie Xin, Xiaoshan Cui, Jiaming Gao, Huiyu Zhang, Fan Guo, Zixin Liu, Shujuan Xu, Ce Cao, Lanlan Li, Hao Guo, Jianhua Fu · 发表于：Biomedicine & Pharmacotherapy · 年份：2025 · DOI：10.1016/j.biopha.2025.118357 · 被引用次数：3 · 研究领域：Viral Infectious Diseases and Gene Expression in Insects、Peptidase Inhibition and Analysis、RNA and protein synthesis mechanisms

Protein post-translational modifications (PTMs), serving as crucial molecular switches regulating protein function and signaling pathways, have emerged as a research hotspot for elucidating the pathogenesis of Ischemic heart disease (IHD) and devising targeted therapeutic approaches. This review provides a comprehensive overview of the principal PTM types associated with IHD, encompassing phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, lactylation and succinylation. It also delves into the molecular mechanisms and key targets of PTMs in IHD pathology, primarily involving myocardial energy metabolism, calcium homeostasis, inflammatory responses, cell death, and myocardial fibrosis. Additionally, this paper evaluates the prospective applications of specific kinase modulators, PTM-targeting modifiers, and gene editing technologies in the treatment of IHD, and proposes a “modificatomics”-oriented precision intervention strategy, which offers a novel perspective for the management of IHD. • The paper revealed the critical role of post-translational modifications (PTMs) in ischemic heart disease. • The paper proposeed precision therapeutic strategies for targeting PTMs. • The paper critically discussed the limitations of PTMs in the treatment of ischemic heart disease and future research directions.