24‐hour activity cycle behaviors and gray matter volume in mild cognitive impairment

作者：Guilherme Moraes Balbim, Nárlon Cássio Boa Sorte Silva, Ryan S. Falck, Arthur F. Kramer, Michelle W. Voss, Teresa Liu‐Ambrose · 发表于：Alzheimer s & Dementia · 年份：2025 · DOI：10.1002/alz.70496 · 被引用次数：4 · 研究领域：Physical Activity and Health、Older Adults Driving Studies、Dementia and Cognitive Impairment Research

INTRODUCTION: The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume. METHODS: Cross-sectional study in 110 adults with MCI. Actigraphy assessed 24-HAC behaviors. FreeSurfer quantified GM. Compositional linear regressions and isotemporal substitution determined 24-HAC composition and GM volume associations. RESULTS: Higher moderate-to-vigorous physical activity (MVPA) relative to remaining behaviors was associated with greater right inferior temporal gyrus volume (ß = 0.30, false-discovery rate (FDR)-corrected-p = 0.030). Higher SB relative to remaining behaviors was associated with lower volume in the same region (ß = -0.45, FDR-corrected-p = 0.015). Reallocating 30 min from SB to MVPA predicted 2.1% greater (ß = 0.06, p < 0.001) and from MVPA to SB predicted 2.8% lower volume (ß = -0.08, p < 0.001). DISCUSSION: Increasing MVPA at the expense of SB may protect GM in regions prone to Alzheimer's disease-related atrophy. TRIAL REGISTRATIONS: ClinicalTrials.gov, NCT02926157, NCT02737878, and NCT02669394. HIGHLIGHTS: The 24-hour behaviors are associated to inferior temporal volume in older adults with mild cognitive impairment (MCI). More moderate-to-vigorous physical activity (MVPA) is linked with greater inferior temporal volume...