Ultrabroad Pressure Sensing, Ultrasensitive, Multi‐Signal Ionogel‐Based Microneedles for Wearable Respiratory Health Monitoring

作者：Tikai Zhang, Bin Sun, Jin Qian, Tianyi Wang, Yushu Zhang, Haijiao Xie, Chen Hua, Zhe Qiang, Jie Ren · 发表于：Advanced Functional Materials · 年份：2025 · DOI：10.1002/adfm.202510723 · 被引用次数：7 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Advanced Fiber Optic Sensors、Non-Invasive Vital Sign Monitoring

Abstract Developing wearable devices with high sensitivity, low‐pressure detection, and multi‐signal monitoring capabilities is critical for the effective diagnosis of respiratory diseases. Here, this work reports a wearable mask that integrates with a printed circuit board (PCB) and Bluetooth Low Energy (BLE) module, in tandem with ionogel‐based microneedle patches (IMN‐1/2) featuring a regularized microarray structure. By leveraging its gradient morphology, IMN‐1/2 achieves a pressure detection limit as low as 0.3 Pa and an ultrahigh sensitivity of 2980.23 kPa⁻¹ in low‐pressure range, enabling the effective monitoring of extremely weak breathing pressure signals. Moreover, hydrophilic N,N ‐dimethylacrylamide (DMAA) of IMN‐1/2 impart the patches with distinct amphiphilic characteristics that limited swelling while allowing for slow, controlled water absorption. When weakly alkaline exhaled breath condensate (EBC) permeates the IMN‐1/2 structure, it alters the charge state of cationic fluorescent crosslinkers, leading to a reduction in fluorescence intensity; this pH‐responsive behavior facilitated long‐term monitoring and potential diagnosis of respiratory alkalosis. Furthermore, the strong adhesion of IMN‐1/2 enhances the sealing integrity of IMN‐1/2‐integrated masks, physically restricting CO 2 inhalation and reducing arterial blood pH values of wearers, thus enabling physical therapy for respiratory alkalosis. This work demonstrates efficient ultralow‐pressure monitoring,...