New advances in oral microbiology and tumor research

作者：Hongjun Liang, Xufang Tan, Di Li, Cheng‐Wen Lin, Huang Suo-yi, Guo-Chao Nie, Xuefeng Guo, Zhijie Zhang, Xiaonian Zhu, Shengkui Tan · 发表于：World Journal of Clinical Oncology · 年份：2025 · DOI：10.5306/wjco.v16.i7.106981 · 被引用次数：5 · 研究领域：Oral microbiology and periodontitis research、Oral health in cancer treatment、Oral Health Pathology and Treatment

Cancer remains a major global health concern, with escalating incidence and mortality rates underscoring the urgent need for novel diagnostic and therapeutic strategies. Increasing evidence has identified the oral microbiota as a critical contributor to tumorigenesis, thereby expanding the understanding of cancer pathogenesis beyond conventional risk factors such as tobacco use and genetic predisposition. This review summarizes recent progress in elucidating the complex relationship between the oral microbiota and various malignancies, particularly oral squamous cell carcinoma, esophageal adenocarcinoma, and pancreatic ductal adenocarcinoma. Pathogenic bacteria, including Porphyromonas gingivalis and Fusobacterium nucleatum , have been implicated in promoting tumor progression through mechanisms involving chronic inflammation, the production of metabolic toxins, and immune evasion. The dysbiosis of the oral microbiota, often driven by lifestyle factors such as poor diet, tobacco use, and alcohol consumption, further exacerbates these carcinogenic processes. Emerging therapeutic approaches including probiotics, oral microbiota transplantation, and CRISPR-based bacterial editing are under investigation for their potential to restore microbial homeostasis and suppress pathogenic species. Additionally, saliva-based microbial biomarkers have shown promise for non-invasive cancer screening. The integration of multi-omics technologies and artificial intelligence-driven platforms is ...