Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women

作者：Tao Li, Juan Tang, Xinghuan Wang, Zhiwu Lin, Chunquan Li, Guogang Liu, Gui Xiao · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-03638-9 · 被引用次数：4 · 研究领域：Ocular Surface and Contact Lens、Skin Protection and Aging、melanin and skin pigmentation

To explore the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women. A total of 1249 perimenopausal female patients who visited Ziyang Hospital of West China Hospital, Sichuan University from January 2021 to December 2023 were included in this study. After screening, the patients were randomly divided into the normal group, control group, estrogen replacement therapy group (ERT), autologous serum group (AS), and estrogen replacement therapy + autologous serum group (ERT + AS). There were 20 cases in each group, totaling 100 cases. Eye surface data, total luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), and endometrial changes were collected before and after treatment in each group. After treatment, the corneal staining area and staining intensity in the ERT + AS group decreased. Compared with the average tear film rupture time of the normal group (15.16 ± 0.73) s, the Control group (5.11 ± 0.45) s decreased to the lowest level while the ERT group (8.27 ± 0.59) s, AS group (8.15 ± 0.72) s, and ERT + AS group (13.37 ± 0.85) s increased, and the ERT + AS group had the most significant increase. Besides, the Schirmer experiment results showed a consistent trend with BUT, with a statistically significant difference (P < 0.05). Meanwhile, our research had shown that after estrogen replacement therapy, FSH and LH in the ERT group and ERT + AS group were sig...