Clinical Efficacy of a Salicylic Acid–Containing Gel on Acne Management and Skin Barrier Function: A 21‐Day Prospective Study

作者：Ye Liu, Yanjun Dan, Jiahong Yang, Xiaofeng He, Jingjing Liu, Yi Yi, Xing Chen, Xue Yin, Weina Song, Yueiqng Niu, Yijie Zheng, Yunfei Ai · 发表于：Journal of Cosmetic Dermatology · 年份：2025 · DOI：10.1111/jocd.70353 · 被引用次数：8 · 研究领域：Acne and Rosacea Treatments and Effects、Advancements in Transdermal Drug Delivery、Dermatologic Treatments and Research

BACKGROUND: Acne vulgaris is a common skin condition characterized by excessive sebum production, inflammation, and compromised skin barrier function. Effective treatments should target both lesion reduction and skin hydration while maintaining tolerability. OBJECTIVE: This study aimed to evaluate the efficacy and tolerability of a salicylic acid-containing gel in reducing sebum levels, improving skin hydration, strengthening the skin barrier, and alleviating acne severity over 21 days. METHODS: A single-center, prospective clinical trial was conducted on 42 participants (37 females, 5 males, mean age: 25.86 ± 6.69 years) with mild-to-moderate acne (IGA grade 2-3) and oily or combination skin. Participants applied the gel twice daily for 21 days. Sebum levels (Sebumeter SM815), trans-epidermal water loss (TEWL, Tewameter TM Hex), and skin hydration (Corneometer CM825) were measured at multiple time points. Acne severity was assessed using the IGA scale, and self-reported satisfaction surveys were collected. RESULTS: Following the follow-up period, sebum levels decreased by 23.65% (p < 0.05), while skin hydration increased by 40.5% (p < 0.05). TEWL decreased by 49.26% (p < 0.05), indicating enhanced skin barrier function. The IGA score improved by 23.81% (p < 0.001), demonstrating a significant reduction in acne severity. All participants (100%) reported satisfaction with the product, with notable improvements in oil control, acne reduction, and skin texture. The gel was well ...