Association of Smoking Cannabis With Cardiovascular Events Among Veterans With Coronary Artery Disease

作者：Salomeh Keyhani, Beth E. Cohen, Marzieh Vali, Katherine J. Hoggatt, Dawn M. Bravata, Peter C. Austin, Emily Lum, Deborah S. Hasin, Carl Grünfeld, Michael G. Shlipak · 发表于：Circulation · 年份：2025 · DOI：10.1161/circulationaha.124.073193 · 被引用次数：6 · 研究领域：Cannabis and Cannabinoid Research、Smoking Behavior and Cessation、Substance Abuse Treatment and Outcomes

BACKGROUND: Whether cannabis is a risk factor for cardiovascular events is unknown. We examined the association between smoking cannabis and cardiovascular events in a cohort of older veterans (66 to 68 years of age) with coronary artery disease. METHODS: The THC Cohort (Heart and Cannabis) comprised 4285 veterans (mean [SD] age, 67.5 [1.01] years; 2% female) with coronary artery disease who were born in 1950 to 1952. Participants were recruited between April 5, 2018, and March 12, 2020, interviewed about health behaviors, and then classified according to their self-reported cannabis smoking status in the previous 30 days. In a separate analysis, we classified participants according to any form of cannabis use (smoking, vaping, or edible use) versus nonuse in the past 30 days. Data on demographic, behavioral, and clinical characteristics were collected by telephone interview and from national Department of Veterans Affairs and Medicare data sources. The primary outcome included a composite of fatal and nonfatal stroke, fatal and nonfatal acute myocardial infarction, and cardiovascular death. The follow-up period for each patient extended from the date of their initial interview until the end of study (June 14, 2022). All participants were followed until they experienced an outcome or until the end of the follow-up period. Survey nonresponse weights and propensity score-based weights were used to reduce bias and confounding. Hazard ratios were estimated using cause-specific ha...