Global, regional, and national estimates of burden and risk factors of female cancers in child-bearing age: A systematic analysis for Global Burden of Disease Study and Bayesian projection to 2030

作者：Guang Chen, S. H. Zhou, Qiaoxin Shi, Yuqiang Xun, Tung-Leong Fong, Ruo-Gu Xiong, Ya Xuan Sun, Junjie Lu, Yige Li, Zheng Li, Guanghui Zhu, Ying Wu, Yang Zhou, Yibin Feng, Karen KL Chan · 发表于：Translational Oncology · 年份：2025 · DOI：10.1016/j.tranon.2025.102473 · 被引用次数：8 · 研究领域：Cancer Risks and Factors、Cervical Cancer and HPV Research、BRCA gene mutations in cancer

BACKGROUND: The prevention, management, and treatment of female cancers among women of childbearing age (WCBA) are crucial strategies for achieving the objectives outlined in the World Health Organization (WHO) Global Breast Cancer Initiative and Cervical Cancer Elimination Initiative. This review aims to provide comprehensive global, regional, and national estimates of the burden of female cancers in women of childbearing age, as well as their attributable risk factors, from 1990 to 2021. METHODS: According to the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 methodology, we estimated the incidence, disability-adjusted life-years (DALYs), and mortality of breast, cervical, ovarian, and uterine cancer among women of childbearing age. Temporal trends were assessed using the age-adjusted percentage change (AAPC). Risk factors were estimated using the population attributable fraction, stratified by socio-demographic index (SDI). Projections to 2030 were generated using a Bayesian model. RESULTS: In 2021, the global incidence of breast, uterine, cervical, and ovarian cancer among WCBA was 561,438 (95 % Uncertainty Interval [UI]: 523,147-602,978), 58,860 (95 % UI: 50,765-65,452), 307,428 (95 % UI: 280,667-335,692), and 85,749 (95 % UI: 75,169-95,090), respectively, corresponding to age-standardized rates per 100,000 population of 28.1 (95 % Confidence Interval [CI]: 28.0-28.1), 2.9 (95 % CI: 2.9-3.0), 15.4 (95 % CI: 15.4-15.5), and 4.3 (95 % CI: 4.3-4.4). ...