Clonal hematopoiesis of indeterminate potential and the risk of breast cancer: a UK Biobank cohort study

作者：Jiayi Lai, Zhihui Xi, Dandan Zhu, Qiyu Zhang, Yifei Yang, Xin Wang, Baijing Xia, Tieying Hou, Huolun Feng · 发表于：International Journal of Surgery · 年份：2025 · DOI：10.1097/js9.0000000000003060 · 被引用次数：4 · 研究领域：Acute Myeloid Leukemia Research、Cancer Genomics and Diagnostics、Genetic Associations and Epidemiology

OBJECTIVE: This study aims to investigate the association between clonal hematopoiesis of indeterminate potential (CHIP) and the risk of breast cancer. METHODS: We analyzed data from the UK Biobank, initially comprised 502 170 participants who met our inclusion criteria. Baseline data on age, body mass index (BMI), alcohol consumption, smoking habits, diet quality scores, physical activity levels, and health status. Whole-exome sequencing data were used to detect CHIP. Logistic regression and Cox proportional hazards (CoxPH) models were employed to assess the association between CHIP and breast cancer risk, adjusting for potential confounders. Additionally, we compared cumulative incident breast cancer cases between CHIP and non-CHIP groups. RESULTS: Univariable analysis showed that CHIP had a higher risk of developing breast cancer (odds ratio [OR] (95% confidence interval [CI]) = 1.200 [1.09-1.31], P = 8.94e-05). This association persisted after adjusting for potential confounders related to lifestyle, inflammation, health status and genetic factors (OR [95% CI] = 1.19 [1.09-1.31], P = 1.77e-04). The correlation remained consistent even after excluding participants with extreme BMI or those diagnosed with breast cancer within 2 or 5 years of follow-up (all OR = 1.18, P < 0.01). Additionally, individuals with CHIP exhibited a significantly higher incidence of breast cancer compared to non-CHIP individuals (Log-Rank P = 5.19e-05). The risk of breast cancer associated with CHI...