Weekly Text Messages to Support Adherence to Oral Pre-Exposure Prophylaxis (PrEP) Among Gay, Bisexual, and Other Cisgender Men Who Have Sex With Men (MSM) and Transgender Women: Pilot Randomized Controlled Trial Nested in PrEP Brasil Study

作者：Luana M. S. Marins, Thiago S. Torres, Ronaldo I. Moreira, Iúri da Costa Leite, Geraldo Marcelo da Cunha, Brenda Hoagland, Lucilene Freitas, Débora Castanheira, Carolina Coutinho, Emília M. Jalil, Mayara Secco Torres Silva, José Valdez Madruga, Beatriz Grinsztejn, Valdiléa G. Veloso · 发表于：Journal of Medical Internet Research · 年份：2025 · DOI：10.2196/72360 · 被引用次数：3 · 研究领域：HIV/AIDS Research and Interventions、Mobile Health and mHealth Applications、HIV-related health complications and treatments

Background: Mobile phones have become popular tools to support public health interventions (mobile health [mHealth]). Text messaging, including SMS, is a simple, low-cost approach for health communication to a large population and offers valuable tools in improving health outcomes. Despite the global advances in HIV treatment and prevention, the HIV epidemic continues to disproportionately affect certain populations such as men who have sex with men (MSM) and transgender women, including in Latin America. Objective: This study aimed to evaluate the effectiveness of SMS text messaging in improving adherence after 1-year provision of oral pre-exposure prophylaxis (PrEP) among MSM and transgender women in Brazil. Methods: Pilot randomized controlled trial nested in the PrEP Brasil study, a prospective, multicenter, open-label implementation study assessing PrEP delivery in the context of the Brazilian Public Health System. Those who agreed to participate in the pilot trial were randomized 1:1 to standard-of-care (SOC) or intervention (SMS text messaging) arm. SMS text messages were launched fully automated weekly to participants for 48 weeks. Adequate adherence to PrEP has been defined as having (1) tenofovir-diphosphate concentration of ≥700 fmol/punch, (2) medication possession ratio of ≥1.07, (3) pill count of ≥90.1%, and (4) self-report (structured questionnaire) of ≥99.9%. Adequate adherence outcomes at week 48 were compared between arms (SMS text messaging vs SOC) using un...