Global burden of substance use disorders in adolescents and young adults aged 10–24 years from 1990 to 2021

作者：He Chen, He Chen, S P Liu, Weiming Wang, Hangyu Shi, Shuai Gao, Yan Yan, Jiufei Fang, Ying Zhan, Huan Chen, Huan Chen, Zhishun Liu · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-11266-6 · 被引用次数：21 · 研究领域：Obesity, Physical Activity, Diet、Child and Adolescent Psychosocial and Emotional Development、Child and Adolescent Health

Substance use disorders (SUDs) among adolescents and young adults aged 10-24 years represent a major global public health challenge, contributing to various medical conditions and significant disease burden. This study analyzed global, regional, and national estimates of the SUD burden within this demographic from 1990 to 2021. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, we analyzed incidence, prevalence, mortality, and disability-adjusted life-years (DALYs) of SUDs among population aged 10-24 years. SUDs in GBD 2021 encompass alcohol and drug use disorders. We calculated age-standardized rates (per 100,000 population) for incidence (ASIR), prevalence (ASPR), mortality (ASMR), and DALYs (ASDR). Health inequalities were assessed using the slope index of inequality (SII) and concentration index. Risk factors were also analyzed. Statistical analyses were performed in R (v4.4.1). In 2021, the global ASIR and ASPR of SUDs among population aged 10-24 years were 614.0 (95% CI 467.6-805.0) and 1557.0 (1234.1-1944.6) per 100,000 population. Substance-specific ASPRs in 2021 included alcohol (651.9, 95% CI 439.0-941.7), cannabis (536.8, 343.5-831.8), opioid use disorders (155.0, 120.0-199.7), etc. The global ASMR and ASDR for SUDs were 1.1 (1.0 to 1.2) and 228.9 (172.4-295.3). From 1990 to 2021, ASIR (average annual percent change [AAPC] - 0.70, 95% CI - 0.71 to - 0.69), ASPR (AAPC - 0.71, - 0.72 to - 0.70), and ASDR (AAPC - 0.60, - 0.63 t...