Trajectories of muscle strength and physical performance preceding dementia in older US and European populations

作者：Youjin Jiang, Yi Ding, Qiuyu Cao, Xianglin Wu, Xiaoran Li, Yu Xu, Yu Xu, Zhiyun Zhao, Min Xu, Jieli Lu, Tiange Wang, Guang Ning, Wei‐Qing Wang, Yufang Bi, Yuchen Xu, Yuchen Xu, Mian Li · 发表于：The Journal of Prevention of Alzheimer s Disease · 年份：2025 · DOI：10.1016/j.tjpad.2025.100296 · 被引用次数：4 · 研究领域：Nutrition and Health in Aging、Balance, Gait, and Falls Prevention、Dementia and Cognitive Impairment Research

BACKGROUND: The association between muscle function and dementia risk remains elusive, as studies suggest that impaired muscle function may act as both a risk factor for and a consequence of dementia, hindering causal inference. OBJECTIVES: We aimed to clarify the temporal relationship between muscle function and incident dementia by investigating non-linear trajectories of muscle function in the years preceding dementia onset in older US and European populations. DESIGN: Case-control study. SETTING: Data were combined from the English Longitudinal Study of Ageing (ELSA, 2004-2018, waves 2-9), Health and Retirement Study (HRS, 2004-2018, waves 7-14), and Survey of Health, Ageing and Retirement in Europe (SHARE, 2004-2017, waves 1-7). PARTICIPANTS: For handgrip strength analysis, 18,335 participants aged 60 and older were included from the ELSA, HRS, and SHARE cohorts. For gait speed analysis, 11,690 participants aged 60 and older were included from the ELSA and HRS cohorts. MEASUREMENTS: Muscle strength was assessed by handgrip strength using a Smedley dynamometer, and physical performance was evaluated by gait speed using the Timed 8-Foot Walk test, with assessments conducted biennially or quadrennially. Dementia was diagnosed using self-reported physician diagnosis and cognitive-functional assessments. Trajectories of muscle strength and physical performance were analyzed on a backward timescale using latent-process mixed models within a nested case-control design. RESULTS:...