Luteolin phospholipid complexes improves the bioavailability of luteolin and exhibits potent protection and high safety in mice with gouty nephropathy

作者：Jiale Mao, Tai Gao, Lingling Wang, Xing Lv, Xu Zhao · 发表于：Natural Product Research · 年份：2025 · DOI：10.1080/14786419.2025.2534681 · 被引用次数：5 · 研究领域：Gout, Hyperuricemia, Uric Acid、Silymarin and Mushroom Poisoning、Pharmacological Effects of Natural Compounds

This study sought to improve luteolin (Lut) solubility and bioactivity via luteolin phospholipid complex (Lut-PC) preparation. Lut-PC was synthesised using solvent evaporation and characterised by multiple techniques. The optimal complexation efficiency reached 95.6% ± 0.83%. SEM, FTIR, and XRD analyses indicated that Lut-PC had an amorphous structure, differing from crystalline Lut, and its formation involved specific molecular interactions. With an octanol-water partition coefficient of 1.44, Lut-PC was more readily adsorbed. In vitro dissolution showed higher cumulative release rates in various media compared to Lut and the physical mixture. In a gouty nephropathy mouse model, Lut-PC effectively reduced uric acid, offered stronger renoprotection than Lut, and had better safety than allopurinol. Thus, phospholipid complexation is a promising method for improving Lut properties, with potential pharmaceutical applications, particularly for gouty nephropathy treatment.