Surgeon-Performed Transoral Ultrasonography for Detection and Staging of Oropharyngeal Cancers

作者：Martin Garset‐Zamani, Gitte Bjørn Hvilsom, Thomas Kjærgaard, Pádraig O’Leary, Kasper Wennervaldt, Mads Bøgh, Christoffer Holst Hahn, Mikkel Kaltoft, Christina Caroline Plaschke, Ronni Mikkelsen, Rikke Norling, Danijela Dejanović, Johanna Maria Hall, Tina Klitmøller Agander, Irene Wessel, Annette Kjær Ersbøll, Christian von Buchwald, Tobias Todsen · 发表于：JAMA Otolaryngology–Head & Neck Surgery · 年份：2025 · DOI：10.1001/jamaoto.2025.1954 · 被引用次数：5 · 研究领域：Head and Neck Cancer Studies、Esophageal Cancer Research and Treatment、Oral Health Pathology and Treatment

Importance: Early-stage oropharyngeal squamous cell carcinoma (OPSCC) is challenging to diagnose using clinical examination and cross-sectional imaging. Ultrasonography performed transorally can provide high-resolution images of oropharyngeal structures; however, whether it improves diagnostic evaluation of patients with suspected OPSCC is unknown, and yet there is a need for improved early detection and T staging. Objectives: To compare the accuracy of clinical examination, ultrasonography, and magnetic resonance imaging (MRI) in detection of oropharyngeal tumors. Design, Setting, and Participants: This multicenter diagnostic clinical trial was conducted in the outpatient clinics of 3 tertiary cancer centers. Consecutive patients with suspected OPSCCs or neck metastases (without visible primary tumors) were screened from February 1, 2023, to June 30, 2024, and those eligible after a clinical examination by a head and neck surgeon were included. Exclusion criteria were a prior head and neck cancer diagnosis or a known histopathologically or imaging-verified oropharyngeal tumor present. Data were analyzed from August 1 to October 31, 2024. Intervention: Surgeon-performed transoral and transcervical ultrasonography of the oropharynx during initial clinical examination followed by cross-sectional imaging (MRI) that was evaluated blinded to results of ultrasonography and histopathologic testing. Main Outcome and Measure: Oropharyngeal tumor detection with reference to final histo...