Diagnostic value and difference of quantitative susceptibility mapping and voxel-based morphological analysis in patients with Alzheimer’s disease and mild cognitive impairment

作者：Yu Fu, Honghai Chen, Shiyun Lou, Yunchu Guo, Fatima Elzahra, Hongling Ren, Hairong Wang, Qingyan Zeng, Ruiyao Song, Chao‐Chun Yang, Yusong Ge · 发表于：Chinese Medical Journal · 年份：2025 · DOI：10.1097/cm9.0000000000003683 · 被引用次数：1 · 研究领域：Advanced MRI Techniques and Applications、Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications

To the Editor: With the aging of the population, the prevalence of Alzheimer’s disease (AD) has increased significantly. Mild cognitive impairment (MCI) is the transition period between normal aging and dementia.[1] Quantitative susceptibility mapping (QSM) allows for the direct measurement of iron metabolism disorders and iron deposition in AD brain tissue, represented as susceptibility (SUS). Voxel-based morphometry (VBM) is widely applied to evaluate gray and white matter lesions in the brain, reflecting differences in the corresponding anatomical structures by quantitatively calculating and analyzing the density or volume of brain gray/white matter for each voxel in the T1WI three-dimensional magnetization prepared rapid acquisition gradient echo (T1WI-3D-MP RAGE) sequence. Herein, we investigated the difference in brain microstructural changes in patients with AD and MCI using QSM and VBM, combined with neuropsychological test results, to evaluate the diagnostic value of QSM and VBM. A total of 67 outpatients and inpatients who visited the Second Hospital of Dalian Medical University from January 2023 to September 2023 were included. All the participants were categorized into three groups: the AD (n = 20), MCI (n = 25), and normal control (NC, n = 22) groups. The diagnostic criteria for AD and MCI matched those of Chu et al[2], for which diagnostic efficiency has been validated in the longitudinal outcome rates of various studies. Clinic-based longitudinal studies of MCI...