Lyophilized apoptotic vesicles restore DNA damage and mitochondria dysfunction to ameliorate radiation enteritis

作者：Bo Yang, Huigen Luo, Xutong Yan, Lingzhi Li, Zhiqing Huang, Yexiang Jiang, Xueli Mao, Songtao Shi, Lan Ma · 发表于：Journal of Nanobiotechnology · 年份：2025 · DOI：10.1186/s12951-025-03592-8 · 被引用次数：5 · 研究领域：Effects of Radiation Exposure、DNA Repair Mechanisms、Autophagy in Disease and Therapy

Radiation therapy for malignant tumor patients often induces radiation enteritis (RE), a condition that impairs their quality of life. Currently, there is no standard treatment regimen available. In this study, we used lyophilized apoptotic vesicles (Lpl-apoVs) from umbilical cord mesenchymal stem cells to treat RE in a murine model. We show that enema administration of lyophilized apoVs can ameliorate intestinal damage in RE mice. Mechanistically, Lpl-apoVs were internalized by intestinal endothelial cells (IECs) to alleviate radiation-induced DNA damage. In addition, mitophagy was identified as a prerequisite for therapeutic efficacy, suggesting that rescue of DNA damage and restoration of mitochondrial quality are collaboratively to ameliorate RE diseased phenotypes. These findings indicate that enema administration of Lpl-apoVs is a novel strategy for RE therapy.