The Sepsis Chain of Survival: A Comprehensive Framework for Improving Sepsis Outcomes

作者：Jorge L. Hidalgo, Vishakha K. Kumar, Samuel Akech, Sheila Nainan Myatra, Shevin T. Jacob, Teresa Bleakly Kortz, Amanda A. Vasquez, Maria Cristina Jiménez Bazzano, Marilia Diaz, Jennifer Del Rio Rodríguez, Ana Luisa Najera Garcia, Rocı́o Girón, Judith Jacobi, Maureen A. Madden, Vinay Nadkarni · 发表于：Critical Care Medicine · 年份：2025 · DOI：10.1097/ccm.0000000000006796 · 被引用次数：24 · 研究领域：Sepsis Diagnosis and Treatment、Cardiac Arrest and Resuscitation、Respiratory Support and Mechanisms

The "Chain of Survival" concept, developed for cardiac arrest, emphasizes a seamless and interconnected set, of time-critical interventions that are not strictly linear, to improve survival. This paradigm of urgent recognition and response to life-threatening conditions has evolved to apply to acute medical conditions, including sepsis. The "Sepsis Chain of Survival" underscores the importance of early recognition, prompt emergency medical services activation, timely antimicrobial administration and appropriate fluid resuscitation, optimized critical care management, effective source control and infection management, and comprehensive post-sepsis care. By adopting this approach, healthcare systems can improve sepsis outcomes through a coordinated, multifaceted strategy. This model highlights the critical role of public and healthcare worker awareness, education, community response, and continuous monitoring. Addressing the importance and interdependence of each link, this framework aims to improve survival rates and patient recovery by ensuring timely and effective sepsis management across diverse resource settings in infants, children, and adults.