Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes

作者：Sam Straw, Oliver Brown, Charlotte Cole, Judith E. Lowry, Marcella Conning-Rowland, Stephe Kamalathasan, Sushma Datla, Maria F. Paton, Ruth Burgess, Michael Drozd, Thomas A Slater, Samuel D. Relton, Eylem Levelt, Klaus K. Witte, Mark T. Kearney, Richard M. Cubbon, John Gierula · 发表于：Circulation Cardiovascular Imaging · 年份：2025 · DOI：10.1161/circimaging.125.018370 · 被引用次数：3 · 研究领域：Cardiovascular Function and Risk Factors、Heart Failure Treatment and Management、Cardiac Imaging and Diagnostics

BACKGROUND: Left ventricular ejection fraction (LVEF) is an essential tool for heart failure (HF) assessment but is limited by load dependence. Additional tools are needed to risk-stratify normal LVEF populations. We aimed to assess the prognostic value of systolic blood pressure-indexed left ventricular end-systolic volume ratio, or cardiac contractility index (CCI). METHODS: In a prospective observational cohort study of people newly diagnosed with HF, we defined characteristics and outcomes associated with LVEF and CCI, including after stratification into HF with reduced ejection fraction or HF with preserved ejection fraction. We used UK Biobank to assess whether CCI is associated with subclinical myocardial dysfunction and incident HF. RESULTS: In people with HF, mortality increased over tertiles of declining CCI ( P <0.001). Within the HF with preserved ejection fraction group, below-median CCI was associated with distinct clinical characteristics and an all-cause mortality risk approximately twice that of those with above median CCI (observed event rate 17.3/100 patient-years versus 8.8/100 patient-years; P <0.001), similar to those with HF with reduced ejection fraction. Modeled as continuous variables, there was a curvilinear relationship between mortality across the detected range of CCI, while there was no clear association with mortality risk across a wide range of LVEF (20%–55%). In UK Biobank for participants without HF and normal LVEF, below-median CCI wa...