Structural Connectome Architecture Shapes Cortical Atrophy in Major Depressive Disorder: A Chinese DIRECT Consortium Study

作者：Yuhao Shen, Chunli Wang, Xiao Chen, Bin Lü, Xue-Ying Li, Zihan Wang, Liping Cao, Guanmao Chen, Jiangshan Chen, Tao Chen, Tao-Lin Chen, Yu-Qi Cheng, Zhaosong Chu, Shi‐Xian Cui, Xi-Long Cui, Zhao‐Yu Deng, Qiyong Gong, Wen-Bin Guo, Cancan He, Zheng-Jia-Yi Hu, Qian Huang, Xinlei Ji, Feng-Nan Jia, Li Kuang, Baojuan Li, Feng Li, Hui-Xian Li, Tao Li, Tao Lian, Yifan Liao, Xiaoyun Liu, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Jianping Lu, Jiang Qiu, Xiaoxiao Shan, Tian-Mei Si, Peng-Feng Sun, Chuanyue Wang, Huaning Wang, Xiang Wang, Ying Wang, Yuwei Wang, Xiao-Ping Wu, Xin-Ran Wu, Yankun Wu, Chunming Xie, Guang-Rong Xie, Peng Xie, Xiu-Feng Xu, Zhenpeng Xue, Hong Yang, Yu Hua, Minlan Yuan, Yonggui Yuan, Ai-Xia Zhang, Jingping Zhao, Ke-Rang Zhang, Wei Zhang, Zijing Zhang, Chao‐Gan Yan, Liping Cao, Guanmao Chen, Jiangshan Chen, Tao Chen, Tao-Lin Chen, Xiao Chen, Yu-Qi Cheng, Zhaosong Chu, Shi-Xian Cui, Xi-Long Cui, Zhao-Yu Deng, Qiyong Gong, Wen-Bin Guo, Cancan He, Zheng-Jia-Yi Hu, Qian Huang, Xin-Lei Ji, Feng-Nan Jia, Li Kuang, Baojuan Li, Feng Li, Hui-Xian Li, Tao Li, Xue-Ying Li, Tao Lian, Yi-Fan Liao, Xiao-Yun Liu, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Bin Lü, Jian-Ping Lu, Jiang Qiu, Xiaoxiao Shan, Yuhao Shen, Tian-Mei Si, Peng-Feng Sun, Chuan-Yue Wang, Chunli Wang, Huaning Wang, Xiang Wang, Ying Wang, Yuwei Wang, Zihan Wang, Xiao-Ping Wu, Xin-Ran Wu, Yankun Wu, Chunming Xie, Guang-Rong Xie, Peng Xie, Xiu-Feng Xu, Zhenpeng Xue, Chao‐Gan Yan, Hong Yang, Yu Hua, Yongqiang Yu, Yongqiang Yu, Minlan Yuan, Yonggui Yuan, Ai-Xia Zhang, Jingping Zhao, Ke-Rang Zhang, Wei Zhang, Zi-Jing Zhang, Jiajia Zhu, Jiajia Zhu, Chao‐Gan Yan, Jiajia Zhu, Jiajia Zhu, Yongqiang Yu, Yongqiang Yu · 发表于：Biological Psychiatry · 年份：2025 · DOI：10.1016/j.biopsych.2025.06.030 · 被引用次数：12 · 研究领域：Functional Brain Connectivity Studies、Mental Health Research Topics、Advanced Neuroimaging Techniques and Applications

BACKGROUND: Cortical morphological alterations are evident in major depressive disorder (MDD), yet the underlying neurobiological processes that contribute to their characteristic spatial pattern remain unclear. METHODS: Large-scale, multisite structural magnetic resonance imaging data from a homogeneous Chinese cohort of 1442 patients with MDD and 1277 healthy control participants were used to calculate cortical morphological measures, which were compared between groups to determine cortical morphological alterations in MDD. A connectome constraint model was then used to examine whether the structural connectome shapes MDD-related cortical morphological alterations, followed by performance of a network diffusion model to identify the epicenters. RESULTS: Group comparisons demonstrated a broadly distributed cortical thickness (CT) reduction in MDD, with the prefrontal cortex affected more prominently. Based on the normative structural connectome, we derived the estimated CT alteration of each brain node according to its connected neighbors and found a strong spatial correlation between the empirical and estimated CT alterations, indicating structural connectome constraint on cortical atrophy in MDD. Concurrently, we identified the left lateral prefrontal cortex as the putative epicenter of cortical atrophy. Moreover, analyses across first-episode, early-stage, and chronic MDD subgroups revealed reduced connectome constraint with increasing illness duration. Additionally, our ...