The relationship between inflammation, osteoporosis, and sleep disturbances: a cross-sectional analysis

作者：Peng Gu, Xiyan Zhao, Zheng Zhang, Bao Zhang, Ying Du, Yanqing Jia, Hao Tang, Yi-Xiang Wang, Tianlin Wen, Zhiwei Jia, Yaohong Wu · 发表于：European journal of medical research · 年份：2025 · DOI：10.1186/s40001-025-02900-0 · 被引用次数：3 · 研究领域：Sleep and related disorders、Nutritional Studies and Diet、Obstructive Sleep Apnea Research

BACKGROUND: Inflammation is a crucial factor in the development of both osteoporosis and sleep disturbances; however, the mechanisms that connect these two conditions are not yet fully understood. This study aims to investigate the relationship among inflammation, osteoporosis, and sleep disturbances, and to assess whether osteoporosis acts as a mediating factor between inflammation and sleep disturbances. METHODS: This study conducted a cross-sectional analysis utilizing data from participants aged 50 and older, sourced from the NHANES database for the years 2005-2010 and 2017-2018. The primary objective was to investigate the associations among inflammatory markers, the Dietary Inflammatory Index (DII), osteoporosis, and sleep disturbances. All participants underwent measurement of inflammatory markers, including C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR). Additionally, DII scores were computed to assess dietary inflammation. To account for potential confounding variables, such as age, sex, and body mass index (BMI), we conducted multivariable regression analyses. RESULTS: The results demonstrated that the 'osteoporosis with sleep disturbances' group exhibited significantly higher CRP levels and DII scores but lower NLR levels compared to the 'without osteoporosis and sleep disturbances' group. Among the four groups, two groups without sleep disturbances showed notably lower CRP levels. After controlling for potential confounding variables, we found a...