Recent advances of engineered probiotics for therapeutic applications

作者：Lu Zhang, Na Chen, Haofeng Chen, Chaoqun Tang, Junyi Wang, Yan Wang, Yang Zhang, Hao Guo, Jifeng Yuan · 发表于：BioDesign Research · 年份：2025 · DOI：10.1016/j.bidere.2025.100039 · 被引用次数：13 · 研究领域：Probiotics and Fermented Foods、Gut microbiota and health、Viral gastroenteritis research and epidemiology

A great number of multifactorial diseases, including neoplastic, metabolic, and autoimmune diseases, have been associated with microbiota dysbiosis. Recently, there has been an increasing understanding of the importance of microbiome and their impact on human health. Advances in synthetic biology have led to the development of probiotics as diagnostic tools and disease treatment approaches. In this review, we briefly summarize recent examples of engineered probiotic-based therapeutics in human diseases, including cancers, gastrointestinal disorders, infectious diseases, and metabolic disorders. Finally, we discuss the challenges and opportunities in developing engineered probiotics for disease treatments.