Recent Advances in Laser‐Induced Phase Separation of PEDOT:PSS for Bioelectronics

作者：Bei'er Zhu, Hao Zhou, Yibo Li, Xiaozheng Wang, Kaichen Xu · 发表于：Advanced Photonics Research · 年份：2025 · DOI：10.1002/adpr.202500104 · 被引用次数：9 · 研究领域：Electron and X-Ray Spectroscopy Techniques、Near-Field Optical Microscopy、Molecular Junctions and Nanostructures

Conductive hydrogels are gaining significant attention for their potential in bioelectronic applications. Among these materials, poly(3,4ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) emerges as a promising candidate due to its intrinsic conductivity, flexibility, and biocompatibility. Recently, laser‐induced phase separation (LIPS) offers a tunable approach for modifying PEDOT:PSS, significantly enhancing its electrical conductivity, wet stability, and electrochemical stability. This technique also allows for high‐spatial‐resolution patterning, rendering it suitable for fabricating on‐demand bioelectronic interfaces. The excellent biocompatibility of the laser‐treated PEDOT:PSS further broadens its potential applications in soft bioelectronic devices. After revealing the LIPS mechanism of PEDOT:PSS and summarizing its key properties, this review offers an overview of its applications in neural signal recording, stimulation, and conduction block. This review establishes a critical connection among the mechanism, properties, and applications of LIPS, thereby paving the way for future research toward advanced bioelectronic applications and beyond.