Global outbreaks of respiratory syncytial virus infections from 1960 to 2025: a systematic review and meta-analysis

作者：Qiuyao Duan, Jinren Pan, Lin Zheng, Zhiwen Jin, Shijian Li, Hangjie Zhang, Xiaofei Fu, Ren Chen, Yu Zhao, Shunwen Qin, Xiaoying Xu, Yin Chen, Sun Jimin, Shelan Liu · 发表于：EClinicalMedicine · 年份：2025 · DOI：10.1016/j.eclinm.2025.103352 · 被引用次数：16 · 研究领域：Respiratory viral infections research、Cystic Fibrosis Research Advances、Virology and Viral Diseases

Background: Respiratory Syncytial Virus (RSV) is a major cause of acute respiratory tract infections (ARTIs) and can trigger outbreaks in vulnerable settings such as nursing homes, pediatric wards, and neonatal intensive care units. This meta-analysis aims to investigate the prevalence, outbreak size, attack rate, and case fatality rate (CFR) of RSV outbreaks reported globally from 1960 to 2025, as well as to assess variations by geographic region, age group, season, outbreak setting, and viral genotypes. Methods: We compiled a global RSV outbreak dataset by searching publications from database inception to January 31, 2025, across MEDLINE, Embase, Global Health, CINAHL, Web of Science, LILACS, OpenGrey, CNKI, Wanfang, and ChongqingVIP. Studies were eligible if they reported data on laboratory-confirmed HRSV outbreaks in any settings (i.e., hospitals, communities, schools, kindergartens, and long-term care facilities) and among all age groups (pediatric and adult patients). There were no language restrictions (English or Chinese). Studies were excluded if they lacked a clear or inconsistent definition or based solely on serology for RSV diagnosis. We used a standardized form to extract publication characteristics, study location, and outbreak and participant information (prevalence, date and season, age, setting, attack rate, CFR, and genotypes). Two authors independently assessed eligibility, with discrepancies being resolved through discussion with a third author. Random-ef...