Multifunctional photothermal-driven PEG-grafted/CuS-loaded dendritic mesoporous organosilicon nanomotors for accelerated wound healing

作者：Shaojun Du, Yueting Li, Yanzhen Feng, Quan Zhou, Jianfeng Wang, Imran Ibrahim Shaikh, Fuqiang Song, Ayesha Younas, Shuanghu Wang, Jian Xiao · 发表于：Chemical Engineering Journal · 年份：2025 · DOI：10.1016/j.cej.2025.165816 · 被引用次数：6 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Nanoplatforms for cancer theranostics、Polydiacetylene-based materials and applications

Infected wounds pose a significant challenge to healing due to bacterial biofilms and persistent inflammation, which conventional therapies often fail to address effectively. To overcome these limitations, this study introduces multifunctional thermophoretic nanomotors (PDC NMs) for the synergistic treatment of infected wounds. The PDC NMs were engineered using dendritic mesoporous organosilicon carriers with tetrasulfide bonds and surface-loaded copper sulfide nanoparticles (CuS NPs). The tetrasulfide bonds enable the glutathione (GSH)-responsive release of hydrogen sulfide (H 2 S). At the same time, the CuS nanoparticles facilitate near-infrared (NIR) light-driven photothermal therapy (PTT) and propulsion, allowing deep biofilm penetration and disruption. Polyethylene glycol (PEG) modification further enhances biocompatibility and colloidal stability. In vitro and in vivo experiments demonstrate that PDC NMs effectively reduce wound size, bacterial survival, and inflammation while promoting angiogenesis, collagen synthesis, and hair regrowth. Notably, by day 9, PDC NMs + NIR treatment achieved an 87.67 ± 1.55 % reduction in wound area and an 85.80 ± 0.23 % decrease in bacterial survival compared to the control groups. Additionally, PDC NMs modulate macrophage polarization from the pro-inflammatory M1 phenotype to the pro-healing M2 phenotype, suppress the expression of pro-inflammatory cytokines (IL-6 and TNF-α), and enhance anti-inflammatory responses (IL-10). Biocompatibi...