Predictive role of the Albumin-Bilirubin score in ICU patients with cirrhosis and sepsis: insights from a large retrospective cohort

作者：Jianjun Wang, Pei Yang, Chuan Qin, Yongwei Huang, Zhaohui Hu, Ruizi Shi, Sirui Chen, Xi Chen, Hua Luo, Jianping Gong, Xintao Zeng, Decai Wang · 发表于：BMC Gastroenterology · 年份：2025 · DOI：10.1186/s12876-025-04111-7 · 被引用次数：9 · 研究领域：Liver Disease and Transplantation、Sepsis Diagnosis and Treatment、Renal function and acid-base balance

BACKGROUND: The albumin-bilirubin (ALBI) score is a valuable prognostic tool for diseases such as hepatocellular carcinoma, heart failure, and acute kidney injury. However, its association with the prognosis of patients with liver cirrhosis and sepsis in the intensive care unit (ICU) remains unclear. METHODS: This retrospective study analyzed data from ICU patients with liver cirrhosis and sepsis admitted to the Beth Israel Deaconess Medical Center between 2008 and 2022. The primary and secondary endpoints were 28-day (short-term) and 90-day (long-term) mortality, respectively. Relationships between mortality risk and the ALBI scores were assessed by Kaplan-Meier, multivariable Cox proportional hazard, and restricted cubic spline (RCS) analyses. The receiver operating characteristic (ROC) curves were used to evaluate the predictive ability of the ALBI score for 28-day and 90-day mortality in these patients. Subgroup analyses were used to explore the associations between the ALBI scores and different patient populations. RESULTS: The study included 2,047 ICU patients with liver cirrhosis and sepsis. Patients with higher ALBI scores had significantly higher 28-day and 90-day mortality rates than those with lower scores (Kaplan-Meier). The ALBI score was an independent predictor of short-term and long-term mortality (multivariable Cox regression). In the fully adjusted model, the hazard ratios (HRs) for the ALBI score as a continuous variable were 1.38 (95% confidence interval [...