Assessment of lipid parameters and its association with risk of stage 1 hypertension: a cohort study in middle-aged and elderly Chinese

作者：Jiabin Lin, Junyan Yu, Chulin Huang, Diaozhu Lin, Feng Li, Yiqin Qi, Ying Liang, Chuan Wang, Leiqin Cai, Yongfeng Huang, Wanting Feng, Na Li, Guojuan Lao, Huisheng Xiao, Chuan Yang, Li Yan, Meng Ren, Kan Sun · 发表于：Aging · 年份：2025 · DOI：10.18632/aging.206280 · 被引用次数：1 · 研究领域：Blood Pressure and Hypertension Studies、Diabetes, Cardiovascular Risks, and Lipoproteins、Lipoproteins and Cardiovascular Health

BACKGROUND: There is a correlation between dyslipidemia and elevated blood pressure, but the relationship between different lipid parameters and elevated blood pressure is inconsistent. Therefore, understanding the impact of dyslipidemia on blood pressure is significant for the prevention and control of ASCVD. Our study is aimed at assessing longitudinally the correlation between lipid parameters and the incidence of stage 1 hypertension in a large Chinese community population. METHODS: This community-based cohort study conducted from 2011 to 2014-2016 included 2,843 eligible individuals aged 40 years or older. The diagnosis of stage 1 hypertension was systolic blood pressure (SBP) 130~139 mmHg and/or diastolic blood pressure (DBP) 80~89 mmHg. We collect data through standardized questionnaires and clinical and biochemical measurements conducted in unified institutions. The relationship between lipid parameters and risk of stage 1 hypertension were estimated using multiple Cox regression analysis. RESULTS: < 0.0001). Multiple Cox regression analyses indicated that, compared to the quartile 1 of TG/HDL-C, quartile 4 was associated with higher risk of incident stage 1 hypertension (model 1: HR = 2.06, 95% CI 1.49-2.84; model 2: HR = 1.95, 95% CI 1.41-2.70; model 3: HR = 1.48, 95% CI 1.05-2.09). CONCLUSIONS: Our study findings suggest that TG/HDL-C is independently associated with the incidence of stage 1 hypertension in the Chinese middle-aged and elderly population.