Differential dynamic functional network connectivity in different motor subtypes of Parkinson's disease

作者：Yu Pan, Hang Qu, Yi Zhao, Zhaoxia Qin, Jiangbing Liu, Wei Wang · 发表于：Brain Research Bulletin · 年份：2025 · DOI：10.1016/j.brainresbull.2025.111460 · 被引用次数：4 · 研究领域：Functional Brain Connectivity Studies、Neurological disorders and treatments、Parkinson's Disease Mechanisms and Treatments

OBJECTIVE: Parkinson's disease (PD) exhibits high heterogeneity in terms of clinical features and prognosis. It can be classified into tremor-dominant (TD) and akinetic rigid-dominant (ARD) subtypes. However, changes in dynamic brain connectivity characteristics in patients with ARD PD remain unclear. Therefore, this study aimed to explore brain networks' dynamic functional connectivity characteristics in patients with TD and ARD PD and their correlation with clinical symptoms. METHODS: This study included 37 patients with TD PD, 33 with ARD PD, and 30 healthy controls (HCs). Resting-state functional magnetic resonance imaging (fMRI) data were obtained from all participants. Independent component analysis (ICA) and graph theory analyses were used to calculate the three groups' dynamic functional network connectivity characteristics. We also examined the correlations between these characteristics and the clinical assessment indices of motor function. RESULTS: Eight functional networks were identified, and four connectivity states were clustered. Compared with the ARD group, the TD group exhibited significantly increased connectivity between the Executive Control Network (ECN) and Visual Network (VIS) in the sparse high-frequency state. In the two tightly coupled states, the TD and ARD groups showed increased connectivity within the default mode network (DMN), decreased connectivity within the sensorimotor network (SMN), and decreased connectivity between the attention network ...