The Golgi apparatus as a strategic target in cancer: mechanisms, diagnosis and therapeutic opportunities

作者：Chao Cui, Chenglu Sun, Peng Yuan, Shibo Tian, Hailong Xie, Funeng Xu, Haohuan Li · 发表于：Journal of drug targeting · 年份：2025 · DOI：10.1080/1061186x.2025.2527867 · 被引用次数：6 · 研究领域：Cellular transport and secretion、Pancreatic function and diabetes、Glycosylation and Glycoproteins Research

The Golgi apparatus, a central hub for protein processing and transportation, plays a critical role in cancer progression and has thus emerged as a highly promising therapeutic target. This review discusses the molecular mechanisms underlying Golgi dysfunction in cancer, along with recent advancements in Golgi imaging techniques that enable precise visualisation of structural and functional alterations within tumours. Furthermore, we highlighted representative applications of Golgi-targeting strategies in cancer diagnosis and treatment, and also discussed future directions for Golgi-targeted therapies, emphasising the potential of the Golgi apparatus as a multidimensional target for cancer management. This study will provide valuable insights for research related to cancer therapeutics.