Impact of the initial administration of an antiretroviral drug with latency reversal properties on the HIV reservoir size

作者：Erick De La Torre Tarazona, Elisa Moraga, Raúl Vaquer, Sonsoles Sánchez-Palomino, Elisa de Lazzari, Laura Luna, Sònia Vicens-Artés, Lucio García‐Fraile, Joaquim Peraire, Mercedes García‐Gasalla, Luz Balsalobre, Sergio Guillén Martínez, Luís F. López‐Cortés, Inma Jarrín, Sergio Serrano‐Villar, José Alcamı́, Santiago Moreno, CoRIS Cohort, Santiago Moreno, Inma Jarrín, David Dalmau, Ma Luisa Masó Navarro, Maria Gonzalez, Féderico García, Eva Poveda, José Antonio Iribarren, Félix Ortega Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, María Ángeles Muñoz‐Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Cristina Marco, Teresa Gómez‐García, María Ángeles Muñoz‐Fernández, Roxana Juárez, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García-Sáez, Iván Agea, José Sánchez–Payá, Juan Carlos Rodrı́guez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrús, Verónica Pérez, Julia Portilla, Héctor Pinargote‐Celorio, María Remedios Alemán Valls, Ana López Lirola, Dácil García, Felícitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, María Inmaculada Hernández, Lucía Romero, Abraham Bethencourt, Daniel Rodríguez, Víctor Asensi, María Rivas-Carmenado, Rafael Magadán, Javier Díaz-Arias, Federico Pulido, Rafael Rubio, Otilia Bisbal, M. Asunción Hernando, David Rial, María Lagarde, Adriana Pinto, Laura Muñoz Bermejo, Mireia Santacreu, Roser Navarro, Juan Martín Torres, José Antonio Iribarren, María José Aramburu, Xabier Camino, Miguel Ángel Goenaga, Ma Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Francisco Carmona-Torre, Ana Bayona Carlos, Maialen Lekuona Sanz, Félix Gutiérrez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael J. Pascual, Marta Fernández, Antonio Galiana, José Alberto Castañeda García, Xavier Barber, Javier García Abellán, Guillermo Telenti, Lucía Guillén, Ángela Botella, Paula Mascarell, Mar Carvajal, Alba de la Rica, Carolina Ding, Lidia García-Sánchez, Nuria Ena, Leandro López, Jennifer Vallejo, Nieves Gonzalo-Jiménez, Montserrat Ruiz, Christian Ledesma, Santiago López, María Espinosa, Ana Quiles‐Jiménez, María Andreo Galera, Juan Carlos López Bernaldo de Quirós, Isabel Gutiérrez, Juan Berenguer, Margarita Ramírez, Paloma Gijón, Teresa Aldámiz‐Echevarría, Francisco Tejerina, Cristina Díez, Leire Pérez, Chiara Fanciulli, Saray Corral, Joaquín Peraire, Anna Rull, Anna Martí, Consuelo Viladés, Beatriz Villar, Lluïsa Guillem, Montserrat Olona, Graciano García‐Pardo, Fréderic Gómez-Bertomeu, Verònica Alba, Sílvia Chafino, Alba Sánchez, Marta Montero, María Tasias, Eva Calabuig, Miguel Salavert, Juan C. Fernández, Rosa Blanes-Hernández, Juan González‐García, Ana Delgado‐Hierro, José Ramón Arribas, Víctor Arribas, José Ignacio Bernardino, Carmen Busca, Joanna Cano-Smith, Julen Cadiñanos, Juan Castro, Luis Escosa, Iker Falces, Pedro Herranz, Víctor Hontañón, Alicia González, Luz Martín‐Carbonero, Mario Mayoral, Rafael Micán, Rosa de Miguel Buckley, Rocío Montejano, Ma Luisa Montes, Luis Ramos‐Ruperto, Berta Rodés, Talía Sainz, Elena Sendagorta, Eulalia Valencia, María del Mar Arcos, Alejandro de Gea Grela, Carlos Manuel Oñoro López, David Dalmau, Marina Martínez, Ángeles Jaén, Mireia Cairó, Javier Martinez-Lacasa, Roser Font, Laura Gisbert, Ignacio de los Santos, Alejandro de los Santos, Lucio García‐Fraile, Enrique García Martín, Ildefonso Sánchez‐Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, María Aguilera García, Santiago Moreno, Santos del Campo, José L. Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez-Granda, Sergio Serrano‐Villar, Ma Jesús Vivancos, Javier Martínez‐Sanz, Alejandro Vallejo, M.J. Gutiérrez Sánchez, José A. Pérez‐Molina, José Manuel Hermida, Erick De La Torre Tarazona, Elena Moreno, Laura Pedraza, Claudio Díaz García, Jorge Dı́az, Alejandro García, Raquel Ron, Enrique Bernal, Antonia Alcaraz, Joaquín Bravo Urbieta, Ángeles Muñoz, Cristina Tomás, Eva Oliver, David M. Selva, Eva García, Ruperto González‐Pérez, Elena Guijarro, Rodrigo Martı́nez, María Dolores Hernández, Féderico García, Clara Martínez, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa García, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Naya Faro, José Antonio Peregrina, Lúcia Helena Garófalo Chaves, M Toril Illescas, Victoria Sánchez, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Melchor Riera, María Luz Pintos Peñaranda, Ma Angels Ribas, Antoni A Campins, Mercedes Garcia-Gazalla, Francisco Fanjul, Javier Murillas, Francisco Homar, Helem Vílchez, Luisa Martín, Antoni Payeras, Jesús Santos, María López, Cristina Gómez, Isabel Viciana, Rosario Palacios, Luís F. López‐Cortés, Núria Espinosa, Cristina Roca-Oporto, Silvia Llaves, Juan Tiraboschi, Arkaitz Imaz, María Saumoy, Julián Olalla, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luís Prada, Onofre Juan Martínez, Lorena Martinez‐Gamboa, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, A. Guirao, Álvaro Mena, Berta Pernas, Pilar Vázquez, Soledad López, Brais Castelo, Carlos Galera, Marian Fernández, Helena Albendín, Antonia Navas Castillo, Asunción Iborra, Antonio Moreno, Maria Angustias Merlos, Inmaculada Chiclano, Inés Suárez‐García, Eduardo Malmierca, Patricia González‐Ruano, M. Pilar Ruiz, José Francisco Pascual, Luz Balsalobre, Ángela Somodevilla, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, Marı́a José Galindo, Sandra Pérez Gómez, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Juárez, Pedro López López, Isabel Machuca, Mario Frías, Ángela Camacho, Ignacio Subías Pérez, Diana Corona, Javier Manuel Caballero, Rafael Rodríguez-Rosado Martinez-Echevarría, Rafael Torres, Juan Macías Sánchez, Pilar Rincón, Luís Miguel Real, Anaïs Corma, Alejandro González‐Serna, Eva Poveda, Alexandre Pérez‐González, Luís Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Maria E. Gallego, Jacobo Daniel Paniagua Alonso, I. Martínez Martínez · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-09474-1 · 被引用次数：5 · 研究领域：HIV Research and Treatment、HIV/AIDS Research and Interventions、HIV/AIDS drug development and treatment

The elimination of the latent viral reservoir remains the main barrier in the quest for a cure for people with HIV (PWH). The administration of latency reversal agents (LRA) at antiretroviral treatment (ART) initiation could improve the effectiveness of strategies aimed at HIV remission. This study assessed the impact of maraviroc (MVC), an antiretroviral drug with HIV latency reversal properties, on the viral reservoir size when it is administered at ART initiation. We conducted a longitudinal observational study in PWH initiating ART with a regimen including (MVC-initiation, n = 12) or not including MVC (non-MVC-initiation, n = 22), or switching to an MVC-containing regimen after achieving an undetectable viral load (VL) (MVC-switch, n = 9). The HIV reservoir size was determined via Alu-LTR and Intact Proviral DNA Assay (IPDA) methods, and cell-associated HIV-RNA (ca-HIV-RNA) by nested-qPCR. Comparative analyses employed mixed multivariate linear models. After a median of 90 weeks, the MVC-initiation group showed a greater reduction in integrated and IPDA-total (7.1- and 4.0-fold, respectively), but not IPDA-intact, HIV-DNA reservoir compared to the non-MVC-initiation group. The reductions in integrated, IPDA-total, and IPDA-intact HIV-DNA levels in the MVC-initiation group were also greater compared to the MVC-switch group (from 5.4 to 13.8-fold). Moreover, no significant differences in the HIV transcriptional activity, assessed by ca-HIV-RNA levels or HIV-RNA/HIV-DNA rati...