Trends in the disease burden of early-onset cancers in China from 1990 to 2021: a systematic analysis of the 2021 Global Burden of Disease study

作者：Jicun Zhu, Tiandong Li, Jiajun Chen, Wenhua Xue, Shuhong Liang, Xie Chen, Xiting Han, Wei Min Hao, Yixin He, Gaoxing Qiao, Xiaoran Duan, Lifeng Li, Jie Zhao · 发表于：BMC Cancer · 年份：2025 · DOI：10.1186/s12885-025-14578-y · 被引用次数：4 · 研究领域：Multiple and Secondary Primary Cancers、Global Cancer Incidence and Screening、Acute Lymphoblastic Leukemia research

BACKGROUND: In recent years, the incidence of early-onset cancers among individuals under 50 years of age has been on the rise. We aimed to analyze the disease burden and temporal trends of early-onset cancers in China, providing a basis for policymakers to develop appropriate strategies. METHODS: We utilized data from the 2021 Global Burden of Disease (GBD) study to describe the changes in early-onset cancers in China from 1990 to 2021, including incidence, mortality and disability-adjusted life years (DALYs). The age-standardized average annual percentage change (AAPC) was estimated using the Joinpoint regression program. RESULTS: From 1990 to 2021, the incidence rate of all early-onset cancers in China increased by 150.72 per 100,000, while the mortality and DALY rates decreased by 4.30 per 100,000 and 279.34 per 100,000, respectively. In 2021, early-onset breast cancer had the highest incidence rate (17.14 per 100,000), and trachea/bronchus/lung cancer had the highest mortality rate (6.15 per 100,000) and DALY rate (292.48 per 100,000). The standardized DALY rate of all early-onset cancers decreased (AAPC = -1.49%, 95% CI: -1.51% to -1.46%), while multiple myeloma, neuroblastoma and other peripheral nervous cell tumors, malignant neoplasm of bone and articular cartilage, kidney cancer, and mesothelioma showed significant increases with AAPC of 4.14% (4.01-4.28%), 3.83% (3.77-3.88%), 1.20% (1.16-1.25%), 0.65% (0.58-0.73%), and 0.33% (0.29-0.37%), respectively. Tobacco cons...