Efficacy of extracranial vertebral artery reconstruction for symptomatic vertebral artery origin in-stent restenosis or occlusion: a ten-year retrospective cohort study

作者：Baoyu Zhang, Jun Sun, Yang Yang, Cong Ling, Chuyang Tai, Ni Mo, Lei Wei, Lixin Huang, Hui Wang, Chuan Chen · 发表于：Annals of Medicine · 年份：2025 · DOI：10.1080/07853890.2025.2529572 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Intracranial Aneurysms: Treatment and Complications、Peripheral Artery Disease Management

Background The optimal management of symptomatic vertebral artery in-stent restenosis or occlusion (SVISRO) after stent-assisted angioplasty (SAA) at the vertebral artery origin remains unclear. This study aimed to investigate the efficacy of vertebral artery reconstruction surgery (VRS) surgery among SVISRO patients.Methods A retrospective study was conducted to analyze the clinical data for SVISRO patients admitted to the Third Affiliated Hospital of Sun Yat-sen University between May 2011 and November 2021. The stroke recurrence and stroke-free rates during the follow-up (FU) period and the patients’ neurological statuses at the last FU were compared between a VRS group and an intensive medical therapy (IMT) group.Results Sixty-two SVISRO patients with an average age of 60.1 ± 8.3 years and an average FU duration of 67.6 ± 32.5 months were studied. The VRS group had significantly fewer stroke recurrences than the IMT group did (5.7% vs. 25.9%, p = 0.034). A 154-month stroke-free rate of 73.8% (95% CI, 24.5% to 93.7%) was observed in the VRS group, whereas the IMT group had a stroke-free rate of 33.9% (95% CI, 17.3% to 75.0%). The hazard ratio (log-rank) between the two groups was 0.234 (95% CI, 0.063–0.871; p = 0.048). The modified Rankin scale score for the VRS group was significantly better than that for the IMT group at the final FU (p = 0.032).Conclusions In patients with SVISRO secondary to SAA, VRS targeting the extracranial vertebral artery (V1-V2) appears to reduce...