A Rare Delayed Neuropsychiatric Encephalopathy After Hyperbaric Oxygen Treatment for Carbon Monoxide Poisoning: A Couple’s Case Report

作者：Sabrina Thelen, William J. Naber, M Reimer · 发表于：Graduate Medical Education Research Journal · 年份：2025 · DOI：10.32873/unmc.dc.gmerj.7.1.002 · 研究领域：Heme Oxygenase-1 and Carbon Monoxide、Neurological and metabolic disorders、Long-Term Effects of COVID-19

Introduction: Carbon monoxide (CO) poisoning is caused when carbon monoxide builds up in the blood, most specifically due to its high binging affinity for the heme structure in hemoglobin.1 This can lead to serious tissue damage and even be fatal. CO poisoning is primarily the result of incomplete combustion of fuels, with common sources domestically and internationally including furnaces, gas heaters, generators, and motor vehicles.2 Symptoms tend to present as neuropsychiatric symptoms, such as dementia, psychosis, parkinsonism, and incontinence. There are few well-researched CO poisoning specific treatments, which suggest supplemental oxygen and hyperbaric oxygen being most effective. We present a case of CO poisoning in two individuals who were both treated with hyperbaric oxygen therapy, Background: Two patients (83-year-old male, 74-year-old female) presented to the emergency department secondary to accidental carbon monoxide poisoning. On scene, emergency services confirmed high Carboxyhemoglobin (COHb) of 35%, and with a Glasgow Coma Scale (GCS) of 4/15 and 3/15 for the male and female respectively; they were subsequently intubated and transferred for emergent hyperbaric oxygen treatment. Due to the post CO non-traumatic brain injury sustained, they were eventually admitted to an inpatient rehabilitation (IPR). On admission, both were fully orientated with progressive improvement of cognition through the initial 2 weeks of their stay. Both patients experienced a drast...