Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu ( Ighm ) as a tissue-level aging biomarker

作者：Fan-Qian Yin, Xiayan Wang, Yong-Xuan Li, Kai-Jing Li, Siyu Ma, Mengjiao Lv, Zhenhua Liu, Wei‐xia Zhong, Yan Liu, Chuan-Fang Tang, Hong-Shi Liu, Yuze Li, Fu‐Hui Xiao, Qing‐Peng Kong · 发表于：Proceedings of the National Academy of Sciences · 年份：2025 · DOI：10.1073/pnas.2423142122 · 被引用次数：4 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Single-cell and spatial transcriptomics、Adipose Tissue and Metabolism

Identifying aging-associated biomarkers applicable for multiple tissues is challenging but crucial for assessing tissue aging. Here, we obtained and analyzed 456 transcriptomes on 17 organs from 30 C57BL/6 J mice with different ages, revealing the consistently upregulated mRNAs of Ighm , C4b , and Ccl8 in most aged organs. This finding received support from independent transcriptomic and proteomic datasets and was further validated through western blot, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence, arguing for both Ighm mRNA and protein as tissue-level aging biomarkers, at least in mice. Its sensitivity to antiaging interventions further emphasizes the significance of Ighm in assessing tissue aging in mice.