Changes in Serum Bilirubin and Total Bile Acids During Biologic Therapy in Patients with Ulcerative Colitis: A Retrospective Study

作者：Zhengyu Ren, Zhe-Wei Zhang, Haichen Li, Paul Fu, Ruixue Wang, Siyao Wang, Y. Li · 发表于：Journal of Inflammation Research · 年份：2025 · DOI：10.2147/jir.s524056 · 被引用次数：1 · 研究领域：Liver Diseases and Immunity、Inflammatory Bowel Disease、Gallbladder and Bile Duct Disorders

Purpose: Ulcerative colitis (UC) requires new non-invasive serum biomarkers for assistance in monitoring due to the low rate of endoscopic follow-up. Previous research indicated reduced levels of serum indirect bilirubin (sIBIL), serum total bilirubin (sTBIL), and serum total bile acids (sTBAs) in UC patients. This study aims to assess their monitoring potential in UC during biologic therapy. Methods: We conducted a retrospective single-center study including 138 UC patients and 150 controls with normal colonoscopy results. The receiver operating characteristic (ROC) curve was used to assess diagnostic value of sIBIL, sTBIL, and sTBAs. Spearman correlation analysis was performed to assess the association between these biomarkers and the severity of both endoscopic findings and clinical symptoms in UC patients. Additionally, changes in serum biomarkers were analyzed in 72 UC patients during biologic therapy, with stratified analyses based on endoscopic remission status. Results: Patients with UC exhibited lower concentrations of sIBIL, sTBIL, and sTBAs compared to the controls ( P < 0.05), and all these biomarkers demonstrated moderate diagnostic value in identifying UC from normal controls ( P < 0.05). sIBIL concentration negatively correlated with disease severity and showed a progressive increase during biologic therapy, particularly in patients achieving endoscopic remission at week 52 ( P < 0.05). The sIBIL concentration in the remission group was significantly higher tha...