Association of C reactive protein triglyceride glucose index with mortality in coronary heart disease and type 2 diabetes from NHANES data

作者：Nan Tang, Xuejin Chen, Haoran Li, Shizhong Cheng, Yanan Hu, Lele Wang, Qiang Zhou, Qingdui Zhang, Hao Ji, Chunmei Qi · 发表于：Scientific Reports · 年份：2025 · DOI：10.1038/s41598-025-10184-x · 被引用次数：25 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Liver Disease Diagnosis and Treatment、Lipoproteins and Cardiovascular Health

Coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM) frequently coexist, significantly elevating the risk of adverse cardiovascular outcomes and mortality. The C-reactive protein-triglyceride-glucose index (CTI), a novel composite marker reflecting both inflammation and insulin resistance, has been associated with poor prognosis in various populations. However, its relationship with all-cause and cardiovascular mortality in patients with coexisting CHD and T2DM remains unclear. Data were obtained from 759 adults with both CHD and T2DM enrolled in the National Health and Nutrition Examination Survey (NHANES) 1999-2010 cycles, with mortality follow-up through December 31, 2019. CTI was calculated and categorized into quartiles. Kaplan-Meier survival analysis, multivariable Cox proportional hazards models, and restricted cubic spline (RCS) analyses were performed to assess the association between CTI levels and risks of all-cause and cardiovascular mortality. Pearson correlation analyses were conducted to evaluate the associations between CTI and key metabolic and inflammatory markers. Subgroup analyses were performed to assess the robustness and consistency of the associations across different clinical strata. During a median follow-up of 109 months, 520 all-cause deaths and 213 cardiovascular deaths were recorded. Higher CTI levels were independently associated with increased risks of both all-cause (HR: 1.68; 95%CI: 1.47-1.92) and cardiovascular mortality (HR: 1.7...