Development and validation of an LDH-focused nomogram for the early prediction of heart failure in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention

作者：Panting Wei, Jingjin Hou, Ruijiao Yu, Kun Na, Jiaqi He, Xiaojie Zhao, Ziqi Liu, Yan Xu, Li Yi, Chenghui Yan, Haibo Yu, Yaling Han · 发表于：Lipids in Health and Disease · 年份：2025 · DOI：10.1186/s12944-025-02649-9 · 被引用次数：7 · 研究领域：Hyperglycemia and glycemic control in critically ill and hospitalized patients、Cardiovascular Function and Risk Factors、Cardiac Ischemia and Reperfusion

BACKGROUND: ST-elevation myocardial infarction (STEMI) patients remain at significant risk of heart failure (HF) despite successful percutaneous coronary intervention (PCI) reperfusion, imposing a considerable public health burden. Lactate dehydrogenase (LDH), a key enzyme in glycolysis, functions as a notable biomarker of cardiac pathology, yet it is frequently often overlooked in clinical practice. This study focused on establishing a nomogram incorporating LDH levels to assess the probability of HF occurring within one year following PCI in individuals who have previously experienced STEMI. METHODS: 527 patients diagnosed with STEMI were initially included in this study. After excluding 71 patients with ejection fractions < 40% and other cardiovascular diseases, the final cohort of 456 patients with STEMI was recruited and randomly assigned to the training and validation sets. To identify potential risk factors linked to HF, both univariate and multivariate logistic regression analyses were conducted, leading to the development of a predictive nomogram. Model performance in terms of discrimination, calibration, and clinical usefulness was validated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analyses (DCA). RESULTS: Patients with STEMI who developed HF within one year exhibited higher LDH levels within 24 hours post-PCI. A nomogram model was constructed that included alcohol drinking, left anterior descending artery involveme...