Use of Blood Oxygenation Level‐Dependent MRI to Predict Clinical Outcomes After Endovascular Revascularization in Peripheral Artery Disease

作者：Shiteng Suo, Hui Tang, Mengqiu Cao, Qihong Ni, Jianxun Qu, Jianrong Xu, Bo Li, Lan Zhang, Qing Lü, Yan Zhou · 发表于：Journal of Magnetic Resonance Imaging · 年份：2025 · DOI：10.1002/jmri.70038 · 被引用次数：4 · 研究领域：Peripheral Artery Disease Management、Advanced MRI Techniques and Applications、Cerebrovascular and Carotid Artery Diseases

ABSTRACT Background Blood oxygenation level‐dependent ( BOLD ) MRI can noninvasively quantify lower extremity perfusion in peripheral artery disease ( PAD ) patients. However, its ability to reflect perfusion change in response to lower extremity revascularization ( LER ) and its prognostic value for clinical outcomes are not fully understood. Purpose To evaluate BOLD MRI response to LER and its predictive value for major adverse cardiovascular events ( MACE ) and major adverse limb events ( MALE ) in PAD patients. Study Type Prospective. Population Forty‐one patients (median age, 73 years; 29 men) undergoing LER for symptomatic PAD. Field Strength/Sequence 3.0 T/BOLD MRI with a multi‐echo gradient‐recalled echo sequence. Assessment Pre‐ and post‐LER BOLD MRI was performed under an ischemia‐hyperemia paradigm. Normalized T2* time course curves were generated in each of 5 calf muscle compartments (anterior, lateral, deep posterior, soleus, and gastrocnemius) and times to peak (TTP), minimum/maximum values, and gradients during hyperemia (Grad) analyzed. Follow‐up was every 6–12 months via hospital records and telephone interviews for MACE and MALE outcomes. Model 1 (clinical factors) and Model 2 (+BOLD MRI) were compared. Statistical Tests Chi‐square test or Fisher's exact test, Student's t‐test or Wilcoxon rank‐sum test, area under the receiver operating characteristic curve (AUC), Kaplan–Meier survival analysis, and Cox proportional hazards regression analysis. Significance ...