The short-, medium- and long-term risk and the multi-organ involvement of clinical sequelae after COVID-19 infection: a multinational network cohort study

作者：Ivan Chun Hang Lam, Yi Chai, Kenneth K. C. Man, Wallis C. Y. Lau, Hao Luo, Xiaoyu Lin, Can Yin, Celine Sze Ling Chui, Xue Li, Qingpeng Zhang, Esther W. Chan, Eric Yuk Fai Wan, Ian Chi Kei Wong · 发表于：Journal of the Royal Society of Medicine · 年份：2025 · DOI：10.1177/01410768251352666 · 被引用次数：2 · 研究领域：Long-Term Effects of COVID-19、Intensive Care Unit Cognitive Disorders、COVID-19 and Mental Health

ObjectivesTo generate comprehensive evidence on the risk of clinical sequelae involving different organ systems over time after coronavirus disease 2019 (COVID-19) infection.DesignMultinational retrospective cohort study.SettingElectronic medical records from the US, UK, France, Germany and Italy standardised to the Observational Medical Outcomes Partnership Common Data Model.ParticipantsA total of 303,251 individuals with a COVID-19 infection between 1 December 2019 and 1 December 2020 and propensity score matched non-COVID-19 comparators from 22,108,925 eligible candidates.Main outcome measuresIncidence of 73 clinical sequelae involving multiple organ systems including the respiratory, cardiovascular, dermatological and endocrine systems over the short- (0-6 months), medium- (6-12 months) and long-term (1-2 years) after COVID-19 infection. The hazard ratio (HR) and 95% confidence interval (95% CI) of individual disease outcomes were estimated using Cox proportional hazard regression.ResultsIndividuals with COVID-19 incurred a greater risk of clinical sequelae involving multiple organ systems including respiratory (France HR 2.23, 95%CI [2.10,2.37] to Italy 13.13 [11.80,14.63]), cardiovascular (Germany 1.39 [1.30,1.50] to US 1.79 [1.74,1.85]) and dermatological (UK 1.13 [1.01,1.25] to Italy 1.77 [1.42,2.21]) disorder over the short-term. While the risk of clinical sequelae has largely subsided during the medium-term, the risk of cardiovascular- (US 1.16 [1.11,1.21], France 1...