Tetrahydromagnolol induces autophagic cell death by targeting the m 6 A reader protein YTHDF2 and enhances the efficacy of anti-PD-1 immunotherapy in pancreatic cancer cells

作者：Guohua Li, Qibiao Wu, Yiping Mou, Yunhao Qiao, Lijun Jin, Qian Shi, Ruonan Zhang, Jie Li, Yitian Sun, Aili Zhang, Haiyang Jiang, Zijing Yang, Zhiyu Zhu, Mengmeng Ma, Xiaoyu Sun, Xinbing Sui · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.112612 · 被引用次数：3 · 研究领域：RNA modifications and cancer、Peptidase Inhibition and Analysis、Galectins and Cancer Biology

This study presents the first evidence that THM promotes cell death in pancreatic cancer cells by inducing autophagy and YTHDF2 is identified as a direct binding target of THM. Targeting YTHDF2 is a critical determiner for THM-induced autophagic cell death and the immunosensitizing effect of THM with anti-PD-1 inhibitor in pancreatic cancer. Therefore, THM may function as a candidate anticancer drug for pancreatic cancer treatment, either alone or in combination with anti-PD-1 immunotherapy.