Preparation and Characterization of Efficient and Safe Rotenone Solid Nanodispersion by Self-Emulsifying Technique

作者：Yunfei Zhang, Xuesheng Lin, Yunlong Qian, Mingda Qin, Shujing Zhang, Lanying Wang, Yanping Luo · 发表于：Preprints.org · 年份：2025 · DOI：10.20944/preprints202507.0505.v1 · 被引用次数：2 · 研究领域：Carbon Nanotubes in Composites、Nanofabrication and Lithography Techniques、Analytical Chemistry and Sensors

Self-emulsifying solid nanodispersion technology is emerging as an attractive strategy to prepare new eco-friendly and efficient nano-formulations due to its simple, energy efficient and easy scale-up process. However, it is still unknown whether this technology can be employed to cope with the drawbacks of botanical insecticides including poor water solubility, rapid photodegradation and limited targeting efficiency. In this study, rotenone (Rot) was selected as a model of botanical insecticides and its solid nanodispersion (Rot–SND) was prepared by a self-emulsifying method combined with parameter optimization. Our target nano-formulation, consisting of 5% Rot, 20% complex surfactants of 8% Ethylan 992 and 12% EL–80, and 75% lactose, exhibited excellent storage stability and significantly improved the pseudo-solubility of Rot by at least 250 times. The average particle size and polydispersity index (PDI) of Rot–SND were 101.19 nm and 0.21, respectively. Rot–SND displayed smaller contact angles and greater retention on both cucumber and cabbage leaves than those of the commercial emulsifiable concentrates (EC). Rot–SND was also more resistant to photodegradation with a degradation rate reduced by 27.01% as compared with the EC. In addition, the toxicity of Rot–SND towards Aphis gossypii was 3.25 times that of the EC, with a median lethal concentration (LC50) of 1.26 µg a.i./mL. Under the field conditions, Rot–SND showed a prolonged duration for A. gossypii control, with a si...